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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|Activation (Act)||2 Antibodies||2 Antibodies|
|Blocking Reagent (BR)||2 Antibodies||3 Antibodies|
|ELISA||3 Antibodies||2 Antibodies|
|Flow Cytometry (FACS)||22 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Intracellular Flow Cytometry (ICFC)||4 Antibodies|
|Western Blotting (WB)||10 Antibodies|
|ELISA (Capture)||1 Antibodies|
|ELISA (Detection)||4 Antibodies|
|Antigen||Inducible T-Cell Co-Stimulator (ICOS) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ICOS antibody is conjugated to PerCP-Cy5.5 Alternatives|
Activation (Act), Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|9 references available|
|Supplier||Log in to see|
Product Details anti-ICOS AntibodyTarget Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2660067) Images
|Cross-Reactivity||Rhesus Monkey, Pig (Porcine)|
|Purification||The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.|
Target Details ICOSProduct Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN2660067) Images back to top
|Alternative Name||CD278 (ICOS Antibody Abstract)|
|Background||ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.|
Application DetailsProduct Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN2660067) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN2660067) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-ICOS Antibody (ABIN2660067)Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Jie, Liang, Hou et al.: "Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 7, pp. 3289-300, 2014 (PubMed).
Hasegawa, Fujimoto, Matsushita et al.: "Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis." in: Rheumatology (Oxford, England), Vol. 52, Issue 2, pp. 242-51, 2013 (PubMed).
Arimura, Shiroki, Kuwahara et al.: "Akt is a neutral amplifier for Th cell differentiation." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11408-16, 2004 (PubMed).
Yagi, Arimura, Dianzani et al.: "Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 783-94, 2003 (PubMed).
Arimura, Kato, Dianzani et al.: "A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses." in: International immunology, Vol. 14, Issue 6, pp. 555-66, 2002 (PubMed).
Buonfiglio, Bragardo, Redoglia et al.: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, 2001 (PubMed).
Coyle, Lehar, Lloyd et al.: "The CD28-related molecule ICOS is required for effective T cell-dependent immune responses." in: Immunity, Vol. 13, Issue 1, pp. 95-105, 2000 (PubMed).
Hutloff, Dittrich, Beier et al.: "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28." in: Nature, Vol. 397, Issue 6716, pp. 263-6, 1999 (PubMed).
Redoglia, Dianzani, Rojo et al.: "Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor." in: European journal of immunology, Vol. 26, Issue 11, pp. 2781-9, 1997 (PubMed).
ImagesProduct Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2660067) back to top