Browse our anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Antibodies

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anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Antibodies (POLD1)
On www.antibodies-online.com are 51 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Antibodies from 17 different suppliers available. Additionally we are shipping Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteins (4) and Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Kits (1) and many more products for this protein. A total of 61 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa products are currently listed.
Synonyms:
125kDa, 5949, CAA61369, CDC2, CG5949, CRCS10, Dmel\\CG5949, Dm Poldelta, dnapol delta, DNA Pol Delta, l(3)72Ac, POLD, POLD3, Poldelta, Pol delta
list all antibodies Gene Name GeneID UniProt
POLD1 5424 P28340
POLD1 18971 P52431
POLD1 59294 O54747

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Most Popular Reactivities for anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Antibodies

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All available anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Antibodies

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Top referenced anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Antibodies

  1. Human Monoclonal POLD1 Primary Antibody for WB - ABIN2853582 : Bermudez, MacNeill, Tappin, Hurwitz: The influence of the Cdc27 subunit on the properties of the Schizosaccharomyces pombe DNA polymerase delta. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for 2853582

  2. Human Monoclonal POLD1 Primary Antibody for WB - ABIN151923 : Kundu, Balusu, Jaiswal, Narayan: Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways. in Carcinogenesis 2007 (PubMed)
    Show all 3 references for 151923

More Antibodies against Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription

Human Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. the pathogenic role of the POLD1-R689W mutation in the development of the human tumor and emphasize the need to experimentally determine the significance of Poldelta variants present in sporadic tumors.

  2. Our work highlights that mutations in different POLD1 domains can lead to phenotypic variability, ranging from dominantly inherited cancer predisposition syndromes, to mild MDPL phenotypes

  3. Germline or somatic variants in the POLE/POLD1 were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.

  4. WRN (show RECQL2 Antibodies) or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta progression across telomeric G-rich repeats, only WRN (show RECQL2 Antibodies) promotes sequential strand displacement synthesis and FEN1 (show FEN1 Antibodies) cleavage.

  5. study of complete exonuclease (show EXO1 Antibodies) domains of POLE and POLD1 in 529 families characterized by presence of familial or early-onset mismatch repair proficient colorectal cancer, and/or APC (show APC Antibodies)-negative and MUTYH (show MUTYH Antibodies)-negative polyposis; results widen the phenotypic spectrum of the POLE/POLD1-associated syndrome and identify novel pathogenic variants

  6. POLD1 is a central mediator of DNA replication and repair, and it is implied in cancer and other pathologies. (Review)

  7. Inactivating POLD1 mutations are associated with colorectal cancer.

  8. Mutations in POLE and POLD1 in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

  9. POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome.

  10. None of the 1188 patients carried the POLD1 p.(Ser478Asn) variant. POLE germline variant carriers are also associated with a microsatellite instable colorectal cancer

Mouse (Murine) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. reducing expression of individual PRMT7 (show PRMT7 Antibodies) target DNA repair genes showed that only the catalytic subunit of DNA polymerase (show POLB Antibodies), POLD1, was able to resensitize PRMT7 (show PRMT7 Antibodies) knock-down cells to DNA-damaging agents.

  2. A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease (show EXOSC10 Antibodies) of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner.

  3. Heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer.

  4. DNA polymerase delta is essential for mammalian early embryogenesis, and the 3'-5' exonuclease (show EXOSC10 Antibodies) activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis

Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Antigen Profile

Antigen Summary

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

Alternative names and synonyms associated with Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1)

  • DNA-polymerase-delta (DNApol-delta) antibody
  • DNA polymerase delta (POLD1) antibody
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3) antibody
  • polymerase (DNA-directed), delta 3, accessory subunit (pold3) antibody
  • polymerase (DNA directed), delta 1, catalytic subunit (POLD1) antibody
  • polymerase (DNA directed), delta 1, catalytic subunit (pold1) antibody
  • polymerase (DNA directed), delta 1, catalytic subunit 125kDa (POLD1) antibody
  • polymerase (DNA directed), delta 1, catalytic subunit (Pold1) antibody
  • 125kDa antibody
  • 5949 antibody
  • CAA61369 antibody
  • CDC2 antibody
  • CG5949 antibody
  • CRCS10 antibody
  • Dmel\\CG5949 antibody
  • Dm Poldelta antibody
  • dnapol delta antibody
  • DNA Pol Delta antibody
  • l(3)72Ac antibody
  • POLD antibody
  • POLD3 antibody
  • Poldelta antibody
  • Pol delta antibody

Protein level used designations for POLD1

CG5949-PA , DNA polymerase delta , DNA polymerase-delta , DNApol-delta-PA , lethal (3) 72Ac , DNA polymerase delta catalytic subunit , DNA-dependent DNA polymerase , DNA polymerase delta subunit 3 , polymerase (DNA directed), delta 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA-directed DNA polymerase delta 3 , DNA polymerase subunit delta 3 , polymerase (DNA directed), delta 1, catalytic subunit 125kDa , DNA-directed DNA polymerase delta 1 , DNA polymerase delta catalytic subunit-like , CDC2 homolog , DNA polymerase subunit delta p125 , DNA polymerase delta 1, catalytic domain , DNA polymerase delta, catalytic subunit

GENE ID SPECIES
39746 Drosophila melanogaster
548092 Glycine max
419053 Gallus gallus
451422 Pan troglodytes
476806 Canis lupus familiaris
549310 Xenopus (Silurana) tropicalis
693601 Macaca mulatta
100051966 Equus caballus
456228 Pan troglodytes
610047 Canis lupus familiaris
719262 Macaca mulatta
734063 Xenopus (Silurana) tropicalis
100052455 Equus caballus
100389890 Callithrix jacchus
100456571 Pongo abelii
100525752 Sus scrofa
5424 Homo sapiens
18971 Mus musculus
59294 Rattus norvegicus
281990 Bos taurus
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