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The proofreading activity of DNA polymerase delta (show POLD1 Proteins) plays a role in shunting DNA mismatch repair to an EXO1 (show EXO1 Proteins)-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease (show EXOSC10 Proteins) activity.
Inhibition of DNA polymerases a, delra and e by AFP (show AFP Proteins) promoter-driven artificial microRNAs may lead to effective growth arrest of AFP (show AFP Proteins)-positive HCC (show FAM126A Proteins) cells,as novel strategy for gene therapy
The results show that the FF483-484 amino acids in the human Poleta (designated F1 motif) are necessary for the interaction of this polymerase with POLD2, the B subunit of the replicative DNA polymerase delta (show POLD1 Proteins), both in vitro and in vivo.
DNA polymerase delta catalytic subunit (show POLD1 Proteins) p125 (show XPC Proteins) induced by mutant type p53 (show TP53 Proteins) is associated with hepatocellular carcinoma invasion.
Results suggest that POLD2 and KSP37 might be potential prognostic biomarkers.
the interaction of PCNA (show PCNA Proteins) with DNA polymerase delta (show POLD1 Proteins) is mediated through the small subunit of the enzyme
The association of PDIP38 (show POLDIP2 Proteins) with pol delta (show POLD1 Proteins) was shown to occur in calf thymus tissue and mammalian cell extracts by GST (show SLCO6A1 Proteins)-PDIP38 (show POLDIP2 Proteins) pull-down and coimmunoprecipitation experiments.
As a first step towards understanding the functional importance of their regulatory subunit interactions, the three-dimensional structure of the p50 (show CD40 Proteins)-p66 (show POLD3 Proteins) heterodimer of human Pol delta (show POLD1 Proteins) has been solved using X-ray crystallography.
the crystal structure of p50 (show CD40 Proteins)*p66 (show POLD3 Proteins)(N) complex featuring oligonucleotide binding and phosphodiesterase domains in p50 (show CD40 Proteins)
A direct interaction between Pold2 and PIAS2 (show PIAS2 Proteins) was confirmed by direct yeast two-hybrid.
The association of PDIP38 (show POLDIP2 Proteins) with pol delta (show POLD1 Proteins) was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 (show POLDIP2 Proteins) pull-down and coimmunoprecipitation experiments.
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
DNA polymerase delta subunit 2
, DNA polymerase delta subunit p50
, Pol delta B subunit (p50)
, polymerase (DNA directed), delta 2, regulatory subunit 50kDa
, DNA-directed DNA polymerase delta 2
, polymerase (DNA directed), delta 2, regulatory subunit