Browse our anti-ATP2C1 (ATP2C1) Antibodies

Full name:
anti-ATPase, Ca++ Transporting, Type 2C, Member 1 Antibodies (ATP2C1)
On www.antibodies-online.com are 87 ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) Antibodies from 22 different suppliers available. Additionally we are shipping ATP2C1 Proteins (7) and ATP2C1 Kits (1) and many more products for this protein. A total of 102 ATP2C1 products are currently listed.
Synonyms:
1700121J11Rik, ATP2C1, ATP2C1A, AW061228, BCPM, D930003G21Rik, HHD, hSPCA1, pmr1, si:dkey-11p23.6, SPCA, Spca1
list all antibodies Gene Name GeneID UniProt
ATP2C1 27032 P98194
ATP2C1 170699  
ATP2C1 235574 Q80XR2

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anti-Human ATP2C1 Antibodies:

anti-Rat (Rattus) ATP2C1 Antibodies:

anti-Mouse (Murine) ATP2C1 Antibodies:

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Top referenced anti-ATP2C1 Antibodies

  1. Human Monoclonal ATP2C1 Primary Antibody for IF, IP - ABIN565309 : Grice, Vetter, Faddy, Kenny, Roberts-Thomson, Monteith: Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for 565309

  2. Human Monoclonal ATP2C1 Primary Antibody for IHC, ELISA - ABIN965621 : Majore, Biolcati, Barboni, Cannistraci, Binni, Crisi, Picardo, Grammatico: ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease. in The Journal of investigative dermatology 2005 (PubMed)
    Show all 2 references for 965621

  3. Human Monoclonal ATP2C1 Primary Antibody for IHC, ELISA - ABIN1724719 : Yokota, Sawamura: Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation. in Journal of dermatological science 2006 (PubMed)
    Show all 2 references for 1724719

  4. Cow (Bovine) Polyclonal ATP2C1 Primary Antibody for IHC, WB - ABIN2781847 : Li, Peng, Xiao, Wang, Liu, Pan, Zhou, Luo: A novel deletion mutation of the ATP2C1 gene in Chinese patients with Hailey-Hailey disease. in Journal of the European Academy of Dermatology and Venereology : JEADV 2008 (PubMed)

More Antibodies against ATP2C1 Interaction Partners

Human ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) interaction partners

  1. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC.

  2. SPCA1a is highly sensitive to the lipid environment and that several SERCA (show ATP2A3 Antibodies) inhibitors, including thapsigargin (Tg), also block SPCA1a activity, although at higher concentrations only. There were differences in the relative contribution of Tg side chains in the inhibition of SERCA1a (show ATP2A1 Antibodies) versus SPCA1a.

  3. In this study, direct DNA sequencing was used to identify ATP2C1 gene mutations in four Chinese families and two sporadic cases with Hailey-Hailey disease.

  4. Two novel ATP2C1 mutations have been found in two unrelated Chinese patients with Hailey-Hailey disease pedigree.

  5. Besides the level of functional ATP2C1 protein, levels of other ATPase (show DNAH8 Antibodies) proteins may influence expressivity of the disease and may also contribute to atypical presentations in three male members of the Hailey Hailey disease family.

  6. This is the first genetic report of HHD from Lebanon in which we identified three novel mutations in ATP2C1 and shed light on the molecular mechanisms and pathogenesis of HHD by linking stress signals like heat shock to the observed phenotypes

  7. We speculate that a novel pathogenic mechanism involving SPCA1, p63 (show RPE65 Antibodies), and IRF6 (show IRF6 Antibodies) may play a role in the skin lesions occurring in HHD.

  8. Data suggest that calcium ATPase (show CA-P60A Antibodies) ATP2C1 gene expression is influenced by an overlapping protein asteroid homolog 1 ASTE1 (show ASTE1 Antibodies) gene.

  9. The CFL-1 (show VPS72 Antibodies)-dependent recruitment of actin to SPCA1 following calcium influx is critical for secretory cargo sorting.

  10. Case Report: haploinsufficiency of ATP2C1 mutations is the causative mechanism of Hailey-Hailey disease.

Zebrafish ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) interaction partners

  1. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC.

Mouse (Murine) ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) interaction partners

  1. The timing, magnitude of TMEM165 (show TMEM165 Antibodies) expression and its Golgi location supports a role for this Golgi Ca2 (show CA2 Antibodies)+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA 1 and 2.

  2. loss of the Golgi Ca(2 (show CA2 Antibodies)+) pump causes Golgi stress, expansion of the Golgi, increased apoptosis, and embryonic lethality and demonstrates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer.

  3. The synthesized siPMR1 can significantly silence the expression of PMR1 and promote the secretion of insulin (show INS Antibodies) in the islet cells in vitro.

  4. Impaired cellular divalent calcium ion Ca2 (show CA2 Antibodies)+ homeostasis and/or the altered targeting of organellar proteins under conditions of SPCA1 knockdown highlight the importance of SPCA1 function for normal neural differentiation.

ATP2C1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with ATP2C1

  • ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1) antibody
  • ATPase, Ca++ transporting, type 2C, member 1 (atp2c1) antibody
  • ATPase, Ca++ transporting, type 2C, member 1 (Atp2c1) antibody
  • ATPase, Ca++-sequestering (Atp2c1) antibody
  • 1700121J11Rik antibody
  • ATP2C1 antibody
  • ATP2C1A antibody
  • AW061228 antibody
  • BCPM antibody
  • D930003G21Rik antibody
  • HHD antibody
  • hSPCA1 antibody
  • pmr1 antibody
  • si:dkey-11p23.6 antibody
  • SPCA antibody
  • Spca1 antibody

Protein level used designations for ATP2C1

ATPase, Ca++ transporting, type 2C, member 1 , ATPase 2C1 , Calcium-transporting ATPase type 2C member 1 , calcium-transporting ATPase type 2C member 1-like , ATP-dependent Ca(2+) pump PMR1 , ATPase, Ca(2+)-sequestering , HUSSY-28 , calcium-transporting ATPase type 2C member 1 , secretory pathway Ca2+/Mn2+ ATPase 1 , ATPase, Ca++-sequestering , calcium-transporting ATPase 2C1 , secretory pathway Ca(2+)-ATPase 1 , secretory pathway Ca(2+)-transporting ATPase

GENE ID SPECIES
100052698 Equus caballus
100157931 Sus scrofa
460694 Pan troglodytes
100173748 Pongo abelii
100411487 Callithrix jacchus
100487845 Xenopus (Silurana) tropicalis
719281 Macaca mulatta
100030308 Monodelphis domestica
100217792 Taeniopygia guttata
100601609 Nomascus leucogenys
27032 Homo sapiens
170699 Rattus norvegicus
559574 Danio rerio
428450 Gallus gallus
477066 Canis lupus familiaris
327663 Bos taurus
235574 Mus musculus
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