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ADAMTS1 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Additionally we are shipping ADAMTS1 Antibodies (130) and ADAMTS1 Proteins (21) and many more products for this protein.
Showing 7 out of 29 products:
Human ADAMTS1 ELISA Kit for Sandwich ELISA - ABIN415114
Tyan, Hsu, Peng, Chen, Kuo, Lee, Shew, Chang, Juan, Lee: Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. in PLoS ONE 2012
Show all 2 Pubmed References
Expression and induction of ADAMTS-1 through receptor-mediated action of progesterone in cumulus cells is one of essential requirements for gonadotropin-regulated cumulus expansion of porcine cumulus-oocyte complexes.
study indicates that disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) participates in bovine endometrial remodeling
Data indicate that ADAMTS1 promoter activity and mRNA expression were increased by forskolin and human chorionic gonadotropin.
Our study demonstrated that altered levels of ADAMTS-1 and aggrecan (show ACAN ELISA Kits) may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients.
Adamts1 acts as an extracellular matrix 'modifier', with miR (show MLXIP ELISA Kits)-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity.
This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
Taken together, our findings suggested that miR (show MLXIP ELISA Kits)-362-3p inhibits the proliferation and migration of VSMCs by directly targeting ADAMTS1, which might provide novel insight into the molecular mechanisms underlying the action of miR (show MLXIP ELISA Kits)-362-3p in atherosclerosis.
ADAMTS1 has diverse roles in angiogenesis, tumor microenvironment and lymphangiogenesis.
Patients with Marfan syndrome showed elevated NOS2 and decreased ADAMTS1 protein levels in the aorta.
Data indicate that serum versican (show Vcan ELISA Kits) levels were significantly decreased in polycystic ovary syndrome (PCOS) patients, and that serum ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) and versican (show Vcan ELISA Kits) levels were significantly and positively correlated with each other.
Findings indicate that ADAMTS-1 has proteolytic functions in the nucleus through its interaction with aggrecan (show ACAN ELISA Kits) substrate in normal and tumoral breast cells.
All ADAMTS (show ADAMTS13 ELISA Kits) tested in our study were expressed in both stable and unstable carotid plaques, especially in smooth muscle cells and macrophages. Analysis of the expression pattern on mRNA level showed significant higher expression of ADAMTS1 in unstable plaques compared with stable plaques.
ADAMTS1 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS1 protein expression.
The developmental arrest of early secondary follicles following furin (show FURIN ELISA Kits) disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice.
Data show that NOTCH1 (show NOTCH1 ELISA Kits) is a target of ADAMTS1 metalloproteinase activity, which reduces Notch (show NOTCH1 ELISA Kits) signaling, leading to increased satellite cell activation.
Reduced tumors in ADAMTS1 knockout mice displayed a paradoxical increase in vascular density and vascular-related genes; a detailed characterization revealed an impaired vasculature, along with a minor infiltration of macrophages. melanoma xenografts showed a relevant induction of its expression in stroma compartments.
Genetic haploinsufficiency of Adamts1 in mice causes thoracic aortic aneurysms and dissections similar to Marfan syndrome.
An ADAMTS1 blocking antibody suppressed the SPARC (show SPARC ELISA Kits)-induced collagen I secretion, indicating that SPARC (show SPARC ELISA Kits) promoted collagen production directly through ADAMTS1 interaction. In conclusion, ADAMTS1 is an important mediator of SPARC (show SPARC ELISA Kits)-regulated cardiac aging.
increased expression of ADAMTS1 protein in macrophages and neutrophils that infiltrated aortic tissues may promote the progression of acute aortic dissection
The resilience of casp1 (show CASP1 ELISA Kits)(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 gene expression.
Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT (show NFATC1 ELISA Kits) or C/EBPbeta (show CEBPB ELISA Kits) transcription factors.
Western blot analyses indicated that aggrecanase (show ADAMTS4 ELISA Kits)-generated proteoglycan (show Vcan ELISA Kits) fragments are produced after SCI.
ADAMTS1 negatively modulates FGF signaling in the Xenopus embryo.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
metalloproteinase with thrombospondin-like motifs-1
, ADAM metallopeptidase with thrombospondin type 1 motif, 1
, A disintegrin and metalloproteinase with thrombospondin motifs 1
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
, ADAM-TS 1
, a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
, a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1
, human metalloproteinase with thrombospondin type 1 motifs
, ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog