anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Antibodies

The membrane-associated protein encoded by ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA4 Proteins (11) and ABCA4 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCA4 24 P78363
ABCA4 11304 O35600
ABCA4 310836  
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Top anti-ABCA4 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$257.99
Details
Mouse Rabbit Un-conjugated WB Western blot analysis of ABCA4 expression in rat eye extract ( Lane 1) and mouse eye extract ( Lane 2). ABCA4 at 256KD was detected using rabbit anti-ABCA4 Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
$240.00
Details
Dog Rabbit Un-conjugated WB Western blot analysis of ABCA4 expression in HEK293T (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ABCA4 using HT29 whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Mouse Rabbit Un-conjugated WB Anti-ABCA4 antibody, Western blotting All lanes: Anti ABCA4  at 0.5ug/ml WB: Mouse Brain Tissue Lysate at 50ug Predicted bind size: 256KD Observed bind size: 256KD 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Anti-ABCA4 antibody, Western blotting WB: U87 Cell Lysate 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Brain, Cortex 100 μL 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant ABCA4, Human. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using ABCA4 antibody. Western blot analysis of extracts of various cell lines, using ABCA4 antibody (ABIN4902806) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details

Top referenced anti-ABCA4 Antibodies

  1. Cow (Bovine) Monoclonal ABCA4 Primary Antibody for IHC (fro), IHC - ABIN447448 : Wiszniewski, Zaremba, Yatsenko, Jamrich, Wensel, Lewis, Lupski: ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. in Human molecular genetics 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ABCA4 Primary Antibody for ELISA - ABIN449914 : Allocca, Doria, Petrillo, Colella, Garcia-Hoyos, Gibbs, Kim, Maguire, Rex, Di Vicino, Cutillo, Sparrow, Williams, Bennett, Auricchio: Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. in The Journal of clinical investigation 2008 (PubMed)

  3. Dog (Canine) Polyclonal ABCA4 Primary Antibody for ELISA - ABIN408723 : Singh, Jalali, Hejtmancik, Kannabiran: Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. in American journal of ophthalmology 2006 (PubMed)

  4. Human Polyclonal ABCA4 Primary Antibody for ELISA - ABIN343052 : McClements, Barnard, Singh, Charbel Issa, Jiang, Radu, MacLaren: An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4-/- Mice. in Human gene therapy 2019 (PubMed)

More Antibodies against ABCA4 Interaction Partners

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. Searching the second hit in patients with inherited retinal dystrophies and monoallelic variants in ABCA4, USH2A and CEP290 by whole-gene targeted sequencing.

  2. There is a large spectrum of ABCA4 sequence variants, including 50 novel variants, in a well-characterised cohort thereby further adding to the unique allelic heterogeneity in STGD1. Approximately half of the cohort harbours missense variants only, indicating a relatively mild phenotype of the ProgStar cohort.

  3. frequent mutation in the ABCA4 gene - p.G1961E - is associated with a relatively mild course of IRD in 81% of cases, even in the presence of a second, severe mutation

  4. A clinically small best-corrected visual acuity (BCVA) loss was observed during 2 years, and the change rate varied depending on baseline BCVA. Eyes without lesion in the fovea had better BCVA at baseline and showed minimal change of BCVA throughout 2 years. Eyes with no or modest acuity impairment but with a foveal lesion at baseline had the fastest loss rate.

  5. The five patients with bull's-eye maculopathy along with a negative ERG had differing genotypes. Mutations were found in the CRX gene (2 patients), the ABCA4 gene (1 patient), and the GUCY2D gene (2 patients).

  6. This article reviews the literature on incidence of IRD caused by mutations in the ABCA4 gene and characteristics of the clinical progression of retinal diseases associated with various types of mutations, and presents analysis of clinical and genetic correlations in terms of the effect the mutation has on the structure or function of the protein [review]

  7. In childhood-onset ABCA4-associated retinopathy, the earliest stages of macular atrophy involve the parafovea and spare the foveola.

  8. Identification of novel pathogenic ABCA4 variants in a Han Chinese family with Stargardt disease has been reported.

  9. describes two clinical cases of patients with splice site mutations in the compound heterozygous state with missense mutations in the ABCA4 gene with various phenotypic manifestations

  10. patients with hereditary retinal disease that carried ABCA4 gene mutations were featured with characteristics of early onset age, rapid progress and severe visual impairment

  11. In Stargardt patients with ABCA4 pathogenic mutations, the photopic negative response of the full-field photopic ERG is a very sensitive disease read-out.

  12. Mutation in ABCA4 gene is associated with Stargardt disease as well as Stickler's Syndrome .

  13. A significant fraction of genetically unexplained STGD1 cases carries p.Asn1868Ile as a second variant. Our findings suggest exceptional differences in disease expression or even nonpenetrance of this ABCA4 variant, pointing toward an important role for genetic or environmental modifiers in STGD1.

  14. These studies corroborate RPE melanin as the major source of NIR-AF but also indicate that bisretinoid lipofuscin, when present at sufficient concentrations, contributes to the NIR-AF signal. Ocular melanin attenuates the SW-AF signal.

  15. the expression and residual activity of ABCA4 mutants play a major role in determining the disease severity of STGD1 patients.

  16. Novel ABCA4 gene mutations were found in Korean patients with STGD1. This study will facilitate better understanding of the relationships between ABCA4 gene mutations and clinical symptoms in Korean patients.

  17. neighboring deep-intronic ABCA4 variants (c.4539+2001G>A and c.4539+2028C>T) result in a retina-specific 345-nt pseudoexon insertion.

  18. Two intronic variants c.4773+3A>G and c.5461-10T>C, both predicted to affect splicing, are indeed disease-causing mutations due to skipping of exons 33, 34, 39 and 40 of ABCA4 gene. The experimental proof that ABCA4 mutations in STGD patients affect protein function is crucial for their inclusion to future clinical trials.

  19. The study broadens the spectrum of ABCA4 mutations with 60 likely pathogenic or pathogenic variants, all associated with Stargardt disease.

  20. Full-field electroretinography is a predictor of the natural course of ABCA4-associated retinal degeneration.

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 functions to recycle retinaldehyde released during proteolysis of rhodopsin in retinal pigment epithelium endolysosomes following daily phagocytosis of distal photoreceptor OS. ABCA4 deficiency in the retinal pigment epithelium may play a role in the pathogenesis of Recessive Stargardt disease 1.

  2. we show that the p.Asn965Ser ABCA4 variant expresses at half the level of WT ABCA4, partially mislocalizes to the endoplasmic reticulum (ER) of photoreceptors, is devoid of N-Ret-PE activated ATPase activity, and causes an increase in autofluorescence and the bisretinoid A2E associated with lipofuscin deposits in retinal pigment epithelial cells as found in Stargardt patients and Abca4 knockout mice.

  3. a comprehensive analysis using RNA-seq identified important roles of the acute stress response in the degenerating retina of Abca4-/-Rdh8-/- mice that are predisposed to retinal degeneration under light stress.

  4. Data indicate that knocking out the ATP-binding cassette transporter Abca4 gene correlated with an increase in all orange pigments.

  5. The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.

  6. Despite pronounced lipofuscin accumulation in the retinal pigment epithelium of Abca4(-/-) mice, ERG and histology showed a slow age-related thinning of the photoreceptor layer similar to wild type controls up to 12 months.

  7. Abca4-deficient mice accumulate more of the toxic bisretinoid A2E than their ABCA4-competent counterparts which contribute to primary cone toxicity and may be associated with macular vision loss

  8. Mutations known to cause Stargardt disease decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activity of ABCA4

  9. The physiological role of Abca4 may include the translocation of 11-cis-retinal complexes across the disk membrane

  10. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 in mice.

  11. Abcr (-/-) mice exhibit progressive photoreceptor cell loss that is detectable at 8 months of age and that has worsened by 11 and 13 months of age.

  12. In 2-month-old Abca4-/- mice, A2E was found in the center of the retinal pigment epithelial tissue; with age, A2E increased across the tissue

  13. A long wavelength fluorescence emission intrinsic to abca4(-/-) retinal explants is shown to emanate from A2PE-H(2).

  14. Studies in mice suggest thet vitamin A supplementation should be avoided in patients with ABCA4 mutations or other retinal or macular dystrophies associated with lipofuscin accumulation in the retinal pigment epithelium.

  15. mice lacking both the ATP-binding cassette transporter 4 (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins critical for all-trans-retinal clearance from photoreceptors, developed severe RPE/photoreceptor dystrophy at an early age

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.

  2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction

  3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function

  4. results indicate that ATP binding cassette protein ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity

Xenopus laevis ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. Evolutionary alterations may increase the retinoid metabolite recycling capacity of ABCA4 and may improve dark adaptation.

ABCA4 Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Gene names and symbols associated with ABCA4

  • ATP binding cassette subfamily A member 4 (ABCA4) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) antibody
  • ATP binding cassette subfamily A member 4 (Abca4) antibody
  • ATP binding cassette subfamily A member 4 (abca4) antibody
  • ATP binding cassette subfamily A member 4 L homeolog (abca4.L) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 4a (abca4a) antibody
  • abc10 antibody
  • abcr antibody
  • armd2 antibody
  • AW050280 antibody
  • cord3 antibody
  • D430003I15Rik antibody
  • ffm antibody
  • rmp antibody
  • rp19 antibody
  • stgd antibody
  • stgd1 antibody
  • zgc:91823 antibody

Protein level used designations for ABCA4

ATP binding cassette transporter , ATP-binding cassette sub-family A member 4 , ATP-binding cassette transporter, retinal-specific , ATP-binding transporter, retina-specific , RIM ABC transporter , RIM protein , photoreceptor rim protein , retina-specific ABC transporter , retinal-specific ATP-binding cassette transporter , stargardt disease protein , ATP-binding cassette 10 , Rim protein , ATP-binding cassette, sub-family A (ABC1), member 4 , ATP-binding cassette, sub-family A member 4 , retinal-specific ATP transporter ABCA4 , retinal-specific ATP-binding cassette transporter-like , ATP-binding cassette, sub-family A, member 4 , retinal ABCA4 transporter , ATP-binding cassette, sub-family A (ABC1), member 4a

GENE ID SPECIES
24 Homo sapiens
11304 Mus musculus
281584 Bos taurus
310836 Rattus norvegicus
424490 Gallus gallus
444852 Canis lupus familiaris
496442 Xenopus (Silurana) tropicalis
745972 Pan troglodytes
100393904 Callithrix jacchus
100440877 Pongo abelii
100479076 Ailuropoda melanoleuca
497268 Xenopus laevis
100605850 Nomascus leucogenys
100725431 Cavia porcellus
100058746 Equus caballus
798993 Danio rerio
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