ABCA4 antibody (C-Term)

Catalog No. ABIN5518717

The Rabbit Polyclonal anti-ABCA4 antibody is suitable to detect ABCA4 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for ABCA4 antibody (C-Term) (ABIN5518717)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ABCA4 Antibody

Binding Specificity: AA 1890-1927, C-Term

Purpose: Anti-ABCA4 Antibody

Sequence: FLLTLLVQRH FFLSQWIAEP TKEPIVDEDD DVAEERQR

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-ABCA4 Antibody (ABIN5518717). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA4, different from the related mouse sequence by eight amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Alternative Name: ABCA4

Background:

Synonyms: Retinal-specific ATP-binding cassette transporter,ATP-binding cassette sub-family A member 4,RIM ABC transporter,RIM protein,RmP,Stargardt disease protein,ABCA4,ABCR,

Tissue Specificity: Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.

Background: ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises ly from ABCR-mediated foveal cone degeneration.

Molecular Weight: 256-300 kDa

Gene ID: 24

UniProt: P78363