Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins (APBB2)

The protein encoded by APBB2 interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. Additionally we are shipping Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Antibodies (67) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APBB2 323 Q92870
APBB2 11787 Q9DBR4
Rat APBB2 APBB2 305338  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
Escherichia coli (E. coli) Human GST tag,His tag 100 μg 15 to 18 Days
$528.00
Details

APBB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Interaction Partners

Human Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. Genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients under methadone maintenance treatment. The haplotype combinations further confirmed this observation, especially in the patients with a positive urine morphine test result. The major genotype and allele type carriers showed a two-time higher risk of amphetamine use than the minor allele type carriers.

  2. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.

  3. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease

  4. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.

  5. FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles

  6. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility.

  7. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF

  8. In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1.

  9. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range.

  10. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell.

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. These data demonstrate a role for FE65 proteins at central and peripheral synapses.

  2. Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency.

  3. FE65 proteins contribute to physiological APP processing and accumulation of amyloid precursor protein metabolic products resulting from NMDA receptor activation

  4. While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.

  5. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF

  6. Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly.

  7. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode

Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Protein Profile

Protein Summary

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with APBB2

  • amyloid beta precursor protein binding family B member 2 (APBB2)
  • amyloid beta (A4) precursor protein-binding, family B, member 2 (Apbb2)
  • amyloid beta precursor protein binding family B member 2 (Apbb2)
  • amyloid beta precursor protein binding family B member 2 (apbb2)
  • amyloid beta (A4) precursor protein-binding, family B, member 2b (apbb2b)
  • 2310007D03Rik protein
  • APBB2 protein
  • DKFZp469I236 protein
  • fe65l protein
  • fe65l1 protein
  • RGD1562438 protein
  • Rirl1 protein
  • si:ch211-201g8.2 protein
  • TR2L protein
  • Zfra protein

Protein level used designations for APBB2

Fe65-like 1 , amyloid beta A4 precursor protein-binding family B member 2 , protein Fe65-like 1 , zinc finger-like protein , amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) , amyloid beta A4 precursor protein-binding, family B, member 2 , amyloid beta (A4) precursor protein-binding, family B, member 2 , amyloid beta A4 precursor protein-binding family B member 2-like , amyloid beta A4 precursor protein-binding, family B, member 2-like , apbb2

GENE ID SPECIES
323 Homo sapiens
11787 Mus musculus
305338 Rattus norvegicus
422781 Gallus gallus
461184 Pan troglodytes
488831 Canis lupus familiaris
514013 Bos taurus
701342 Macaca mulatta
100144693 Xenopus (Silurana) tropicalis
100174507 Pongo abelii
100409701 Callithrix jacchus
100463683 Ailuropoda melanoleuca
100353587 Oryctolagus cuniculus
100718217 Cavia porcellus
564990 Danio rerio
Selected quality suppliers for Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins (APBB2)
Did you look for something else?