Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins (APBB2)

The protein encoded by APBB2 interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2.

list all proteins Gene Name GeneID UniProt
Human APBB2 APBB2 323 Q92870
Mouse APBB2 APBB2 11787 Q9DBR4
Rat APBB2 APBB2 305338  
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Top Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
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Escherichia coli (E. coli) Human GST tag,His tag 100 μg Log in to see 15 to 18 Days
$528.00
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More Proteins for Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Interaction Partners

Human Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.

  2. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease

  3. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.

  4. FE65L1 potentiates gamma-secretase processing of APP (show APP Proteins) CTFs. This requires binding of FE65L1 to APP (show APP Proteins) and APP (show APP Proteins) CTFs. Enhanced APP (show APP Proteins) CTF (show NFIA Proteins) processing can be detected in early endosome vesicles

  5. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility.

  6. the apoptosis inhibitory domain of FE65 (show APBB1 Proteins)-like protein 1 regulates both apoptotic and caspase (show CASP3 Proteins)-independent programmed cell death mediated by TNF (show TNF Proteins)

  7. In response to TNF (show TNF Proteins), Zfra is upregulated and modulates TNF (show TNF Proteins)-mediated cell death via interacting with TRADD (show TRADD Proteins), FADD (show FADD Proteins) and RIP (show HRB Proteins) (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB (show NFKB1 Proteins), p53 (show TP53 Proteins), WOX1 (show WWOX Proteins), and JNK1 (show MAPK8 Proteins).

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) interaction partners

  1. These data demonstrate a role for FE65 (show APBB1 Proteins) proteins at central and peripheral synapses.

  2. Findings show that amyloid precursor protein (show APP Proteins)-binding proteins FE65 (show APBB1 Proteins) and FE65L1 are essential for the maintenance of lens transparency.

  3. FE65 (show APBB1 Proteins) proteins contribute to physiological APP (show APP Proteins) processing and accumulation of amyloid precursor protein (show APP Proteins) metabolic products resulting from NMDA receptor activation

  4. While mitogen activated protein kinase 8 (JNK1 (show MAPK8 Proteins)) is a downstream effector of the Tumor Necrosis Factor (TNF (show TNF Proteins)) signaling, Zfra regulation of the TNF (show TNF Proteins) cytotoxic function is likely due to its interaction, in part, with JNK1 (show MAPK8 Proteins).

  5. the apoptosis inhibitory domain of FE65 (show APBB1 Proteins)-like protein 1 regulates both apoptotic and caspase (show CASP3 Proteins)-independent programmed cell death mediated by TNF (show TNF Proteins)

  6. Targeted deletion of two members of the FE65 (show APBB1 Proteins) family of adaptor proteins, FE65 (show APBB1 Proteins) and FE65L1, results in cortical dysplasia and suggests that FE65 (show APBB1 Proteins) proteins are involved in basement membrane assembly.

  7. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein (show APP Proteins) reveals a novel peptide binding mode

Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2) Protein Profile

Protein Summary

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with APBB2

  • amyloid beta precursor protein binding family B member 2 (APBB2)
  • amyloid beta (A4) precursor protein-binding, family B, member 2 (Apbb2)
  • amyloid beta precursor protein binding family B member 2 (Apbb2)
  • amyloid beta precursor protein binding family B member 2 (apbb2)
  • amyloid beta (A4) precursor protein-binding, family B, member 2b (apbb2b)
  • 2310007D03Rik protein
  • APBB2 protein
  • DKFZp469I236 protein
  • fe65l protein
  • fe65l1 protein
  • RGD1562438 protein
  • Rirl1 protein
  • si:ch211-201g8.2 protein
  • TR2L protein
  • Zfra protein

Protein level used designations for APBB2

Fe65-like 1 , amyloid beta A4 precursor protein-binding family B member 2 , protein Fe65-like 1 , zinc finger-like protein , amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) , amyloid beta A4 precursor protein-binding, family B, member 2 , amyloid beta (A4) precursor protein-binding, family B, member 2 , amyloid beta A4 precursor protein-binding family B member 2-like , amyloid beta A4 precursor protein-binding, family B, member 2-like , apbb2

GENE ID SPECIES
323 Homo sapiens
11787 Mus musculus
305338 Rattus norvegicus
422781 Gallus gallus
461184 Pan troglodytes
488831 Canis lupus familiaris
514013 Bos taurus
701342 Macaca mulatta
100144693 Xenopus (Silurana) tropicalis
100174507 Pongo abelii
100409701 Callithrix jacchus
100463683 Ailuropoda melanoleuca
100353587 Oryctolagus cuniculus
100718217 Cavia porcellus
564990 Danio rerio
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