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The protein encoded by ANG is an exceedingly potent mediator of new blood vessel formation.
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Data show that phospholipase D2 (PLD2 (show PLD2 Proteins))-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (show MOK Proteins) (ccRCC) cells.
The results revealed that PCNA (show PCNA Proteins) is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA (show PCNA Proteins) colocalize in the cytoplasm, suggesting that they may interact in this compartment.
RNase 5 suppressed p27 (show PAK2 Proteins) and up-regulated cyclin D1 (show CCND1 Proteins), D3, and E by activating PI3-kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) in CECs to initiate cell cycle progression
When yeast genetic interaction partners held in common between human OPTN (show OPTN Proteins) and ANG were validated in mammalian cells and zebrafish, MAP2K5 (show MAP2K5 Proteins) kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy
There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 (show CADM4 Proteins) in gastric or colon adenocarcinomas
Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 (show MMP2 Proteins) through modulation of DNMT3b (show DNMT3B Proteins) functions.
(31) RRR (show RRS1 Proteins)(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53 (show TP53 Proteins)-mediated apoptosis and angiogenesis in cancer cells.
Study shows that plexin-B2 (PLXNB2 (show PLXNB2 Proteins)) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
Delivery of the therapeutic human genes VEGF (show VEGFA Proteins) and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5 (show PSEN2 Proteins)-VEGF (show VEGFA Proteins)+Ad5 (show PSEN2 Proteins)-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons.
Ang down-regulate the expression of Col (show HDAC1 Proteins)-I, alpha-SMA (show SMN1 Proteins) and TGF-beta1 (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins)/3 and subsequently inhibits fibroblast-myofibroblast transition.
Association analyses revealed the significant associations (P < 0.05) between the porcine ANG g. 149G>T polymorphism and mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean platelet volume (MPV) and platelet-large cell ratio (P-LCR).
ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation.
angiogenin and ILK (show ILK Proteins) signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis
RNase 4 (show RNASE4 Proteins) and RNase 5/ang 1 (show ANGPT1 Proteins) are unique among the RNase A (show RNASE1 Proteins) ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.
ANG plays an important role in neurite pathfinding and this has implications for amyotrophic lateral sclerosis.
Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen.
All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT (show AKT1 Proteins)-induced PIN (show DYNLL1 Proteins), indicating an essential role of ANG in AKT (show AKT1 Proteins)-mediated cell proliferation and survival.
Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 (show HIF1A Proteins) is sufficient and required to upregulate angiogenin expression during hypoxia.
This study is the first to demonstrate that hypoxia upregulates Ang1 (show ANGPT1 Proteins) expression via HIF2alpha (show EPAS1 Proteins)-mediated transcriptional activation in pericytes, which plays a key role in angiogenesis.
rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infafrction.
bovine angiogenin is the substance mainly responsible for the inhibitory effect of bovine milk on osteoclast-mediated bone resorption
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
, epididymis luminal protein 168
, ribonuclease 5
, angiogenin, ribonuclease A family, member 1
, angiogenin ribonuclease 1