Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) Proteins (BUB1)

BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Antibodies (153) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BUB1 699 O43683
Rat BUB1 BUB1 296137  
BUB1 12235 O08901
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Top BUB1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
€12,160.77
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
€12,160.77
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
€720.35
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
€288.00
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Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
€543.09
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BUB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) Interaction Partners

Human Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Conserved domain 1 (CD1) in human Bub1 binds directly to Mad1 and a phosphorylation site exists in CD1 that stimulates Mad1 binding and SAC signalling.

  2. Finally, the authors show that the kinetochore localization of BUB1 and BUBR1 decreases with the age of the oocyte donors. This could contribute to oocyte aneuploidy.

  3. Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.

  4. MiR-490-5p could regulate TGFbeta/Smad signaling pathways by inhibiting BUB1.

  5. Therefore, Mps1 promotes checkpoint activation through sequentially phosphorylating Knl1, Bub1, and Mad1. This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 and to kinetochore-microtubule attachment.

  6. Chromosomal rearrangement resulting in BUB1 haploinsufficiency identified in a patient with polycystic liver disease. BUB1 may imply germline causes of genetic instability in PLD.

  7. Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions.

  8. Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.

  9. Study shows that BUB1beta and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.

  10. Bub1 may be associated with cancer stem cell potential.

  11. Both Bub1 and BubR1 bind stably to Bub3 that is required for kinetochore localization of the proteins

  12. Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint complex formation.

  13. Data show that mitotic checkpoint kinase Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.

  14. human BUB1 does not associate stably with the MAD2 activator MAD1 (also known as MAD1L1) and, although required for accelerating the loading of MAD1 onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 there

  15. MAD2L1 and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

  16. Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.

  17. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities.

  18. BUB1B expression was highly correlated to CDC20 and CCNB1 expression in multiple myeloma cells, leading to increased cell proliferation.Bub1 expression promotes cell proliferation and leads to poor survival in multiple myeloma patients

  19. BubR1 is a component of the Mitotic checkpoint complex and was reported to be overexpressed in Breast cancer. BubR1 overexpression was correlated with poor survival in early stage Breast cancer patients.

  20. Bub1 in complex with LANA recruits PCNA to regulate Kaposi's sarcoma-associated herpesvirus latent replication and DNA translesion synthesis.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities.

  2. It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.

  3. Results establish that Bub1 has oncogenic properties and suggest that Aurora B is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.

  4. It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  5. mutations of Bub1 and BubR1 found in Brca2- mutant mice indeed are responsible for the chromosome instability in Brca2-mutated tumors

  6. Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.

  7. Bub1 is important for mediating cell death when chromosomes missegregate.

  8. Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.

  9. Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.

  10. Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.

  11. Bub1 insufficiency can drive tumor formation through tumor suppressor gene loss of heterozygosity, but only in restricted genetic and cellular contexts

BUB1 Protein Profile

Protein Summary

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.

Gene names and symbols associated with BUB1

  • BUB1 mitotic checkpoint serine/threonine kinase (BUB1)
  • BUB1 mitotic checkpoint serine/threonine kinase (bub1)
  • BUB1 mitotic checkpoint serine/threonine kinase (Bub1)
  • BUB1, mitotic checkpoint serine/threonine kinase (Bub1)
  • AL022991 protein
  • Bub1a protein
  • BUB1L protein
  • C80208 protein
  • D2Xrf87 protein
  • hBUB1 protein
  • xbub1 protein

Protein level used designations for BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog , mitotic checkpoint serine/threonine-protein kinase BUB1 , budding uninhibited by benzimidazoles 1 , budding uninhibited by benzimidazoles 1 homolog , mitotic spindle checkpoint kinase , putative serine/threonine-protein kinase , mBUB1

GENE ID SPECIES
100064049 Equus caballus
459484 Pan troglodytes
780291 Xenopus (Silurana) tropicalis
699 Homo sapiens
296137 Rattus norvegicus
12235 Mus musculus
100682599 Canis lupus familiaris
514777 Bos taurus
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