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BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Antibodies (157) and many more products for this protein.
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Small sequence differences in Bub1 and BubR1 (show BUB1B Proteins) direct Bub3 (show BUB3 Proteins) to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.
MiR (show MLXIP Proteins)-490-5p could regulate TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathways by inhibiting BUB1.
Therefore, Mps1 (show IDUA Proteins) promotes checkpoint activation through sequentially phosphorylating Knl1 (show CASC5 Proteins), Bub1, and Mad1 (show MXD1 Proteins). This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 (show IDUA Proteins) and to kinetochore-microtubule attachment.
Chromosomal rearrangement resulting in BUB1 haploinsufficiency identified in a patient with polycystic liver disease. BUB1 may imply germline causes of genetic instability in PLD.
Results report that BubR1 (show BUB1B Proteins) and RepoMan bind directly to PP2A (show PPP2R4 Proteins)-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser (show SIGLEC1 Proteins) residue enhances binding. RepoMan and BubR1 (show BUB1B Proteins) bind B56 using both hydrophobic and electrostatic interactions.
Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.
Study shows that BUB1beta (show BUB1B Proteins) and PDZ binding kinase (show PBK Proteins) are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Bub1 may be associated with cancer stem cell potential.
Both Bub1 and BubR1 (show BUB1B Proteins) bind stably to Bub3 (show BUB3 Proteins) that is required for kinetochore localization of the proteins
Bub1-Plk1-mediated phosphorylation of Cdc20 (show CDC20 Proteins) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (show BUB3 Proteins) complex formation.
Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B Proteins) recruitment and localizes antagonistic checkpoint activities.
It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.
Results establish that Bub1 has oncogenic properties and suggest that Aurora B (show AURKC Proteins) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.
It seems that Sgo1 (show SGOL1 Proteins) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
mutations of Bub1 and BubR1 (show BUB1B Proteins) found in Brca2 (show BRCA2 Proteins)- mutant mice indeed are responsible for the chromosome instability in Brca2 (show BRCA2 Proteins)-mutated tumors
Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.
Bub1 is important for mediating cell death when chromosomes missegregate.
Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.
Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog
, mitotic checkpoint serine/threonine-protein kinase BUB1
, budding uninhibited by benzimidazoles 1
, budding uninhibited by benzimidazoles 1 homolog
, mitotic spindle checkpoint kinase
, putative serine/threonine-protein kinase