Cell Death-Inducing DFFA-Like Effector A Proteins (CIDEA)

CIDEA encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. Additionally we are shipping CIDEA Antibodies (98) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CIDEA 1149 O60543
CIDEA 12683 O70302
Rat CIDEA CIDEA 291541  
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Top CIDEA Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 50 μg Log in to see 13 to 16 Days
$440.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$749.00
Details

CIDEA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Cell Death-Inducing DFFA-Like Effector A (CIDEA) Interaction Partners

Human Cell Death-Inducing DFFA-Like Effector A (CIDEA) interaction partners

  1. Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 (show UCP1 Proteins) activity.

  2. These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.

  3. Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases.

  4. The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders

  5. the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated.

  6. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma (show MOK Proteins).

  7. Insulin (show INS Proteins) regulates CIDEA and CIDEC (show CIDEC Proteins) expression via PI3K (show PIK3CA Proteins), and it regulates expression of each protein via Akt1 (show AKT1 Proteins)/2-and JNK2 (show MAPK9 Proteins)-dependent pathways, respectively, in human adipocytes.

  8. The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG

  9. CIDEA binds to liver X receptors and regulates their activity in vitro.

  10. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets

Mouse (Murine) Cell Death-Inducing DFFA-Like Effector A (CIDEA) interaction partners

  1. results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes.

  2. The authors show demonstrate an essential role of an amphipathic helix in CIDEA, which facilitates embedding in the lipid droplet phospholipid monolayer and binds phosphatidic acid (PA).

  3. Data (including data from studies in knockout mice) suggest Cideb (show CIDEB Proteins) promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec (show CIDEC Proteins) promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.

  4. Cidea is highly associated with adiposity and insulin (show INS Proteins) resistance, whereas Cidec (show CIDEC Proteins) is related to insulin (show INS Proteins) sensitivity

  5. data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity

  6. maternal diet modulates the age-associated changes in Cidea expression leading to the development of fatty liver

  7. Cidea is a crucial regulator of sebaceous gland lipid storage and sebum lipid secretion in mice.

  8. acts as transcriptional coactivator of C/EBPbeta (show CEBPB Proteins) in mammary glands to control lipid secretion

  9. Cidea is a critical regulator of free fatty acid-induced apoptosis as a novel downstream target for Foxo1 (show FOXO1 Proteins) in pancreatic beta-cells

  10. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets

Cow (Bovine) Cell Death-Inducing DFFA-Like Effector A (CIDEA) interaction partners

  1. These results suggest that CIDE-A and UCP1 (show UCP1 Proteins) are regulated by insulin (show INS Proteins) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.

CIDEA Protein Profile

Protein Summary

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.

Gene names and symbols associated with CIDEA

  • cell death-inducing DFFA-like effector a (CIDEA)
  • cell death-inducing DNA fragmentation factor, alpha subunit-like effector A (Cidea)
  • cell death-inducing DFFA-like effector a (Cidea)
  • cell death-inducing DFFA-like effector a (cidea)
  • cell death-inducing DFFA-like effector a L homeolog (cidea.L)
  • AW212747 protein
  • cide-a protein
  • CIDEA protein
  • MGC89985 protein

Protein level used designations for CIDEA

cell death activator CIDE-A , cell death-inducing DFFA-like effector A , cell death-inducing DFFA-like effector a , cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

GENE ID SPECIES
1149 Homo sapiens
12683 Mus musculus
468605 Pan troglodytes
490559 Canis lupus familiaris
527051 Bos taurus
768659 Gallus gallus
291541 Rattus norvegicus
703318 Macaca mulatta
493350 Xenopus (Silurana) tropicalis
495322 Xenopus laevis
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