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mouse homolog is a component of the centrosome [RGD, Feb 2006].. Additionally we are shipping Centrin 1 Antibodies (54) and and many more products for this protein.
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Data identified AtCEN1 and 2 (yeast Cdc31 homolog) as a component of nuclear pore complexes.
Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing.
The crystal structure exhibits three structural features, i.e. four Ca2+ equally occupied at each EF-hand motif, structural changes accompanying helix motion at the N- and C-lobes, and adoption of N-C type dimerization when Ca2+ binds to EF-hand I and II in the N-lobe.
Experiments utilizing mouse embryo fibroblasts (MEFs) demonstrated the feasibility of real-time imaging, and showed that EGFP-Centrin1 expression mirrored the endogenous centrosome cycle, undergoing precisely one round of duplication through the cell cycle. Moreover, experiments using embryo and adult mouse tissues demonstrated that EGFP-Centrin1 specifically mirrors the localization of endogenous centrosomes.
role in late steps of spermiogenesis and spermatid maturation
Immunostaining of seminiferous tubules revealed that cells in layer containing spermatogonia showed colocalization of SUMO-2/3 with centrin-1 in cytoplasmic spots. Binding of centrin-1 and SUMO-2/3 appears to be calcium dependent.
Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells
Cen1 and Cen2 contribute to the centrin-transducin complex and potentially participate in the regulation of transducin translocation through the photoreceptor cilium
important spectral and hydrodynamic characteristics of human Centrin-1, accounting that HsCentrin-1 has moderate affinity for Ca(2+). Centrin-1 does not gain structure as seen by far- and near-UV circular dichroism, rather there is a loss of ellipticity, though inconsiderable upon binding Ca(2+).
A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.
CETN1 is overexpressed in breast cancer tissue and promotes cells'proliferation, tumor growth and metastasis.
These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis.
mouse homolog is a component of the centrosome
centrin, EF-hand protein, 1
, centrin 1
, testis-specific murine centrin
, EF-hand protein
, calcium binding protein