Ceramide Synthase 6 Proteins (CERS6)

May be involved in sphingolipid synthesis or its regulation (By similarity).. Additionally we are shipping Ceramide Synthase 6 Antibodies (56) and Ceramide Synthase 6 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CERS6 253782 Q6ZMG9
CERS6 241447 Q8C172
Rat CERS6 CERS6 366065  
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Top Ceramide Synthase 6 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
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Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details

CERS6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for Ceramide Synthase 6 (CERS6) Interaction Partners

Human Ceramide Synthase 6 (CERS6) interaction partners

  1. both SphK1 overexpression and S1P addition increased mTOR phosphorylation as shown by ELISA, while S1PR2 inhibition had the inverse effect. These data suggest that CerS6 and SphK1 regulate mTOR signaling in breast cancer cell proliferation. Moreover, mTOR activity can be regulated by the balance between S1P and C16ceramide, which is generated by CerS6.

  2. ceramide synthase (CerS)6 was specifically up-regulated in zone 3 hepatocytes in alcoholic steatosis

  3. This study has shown that by direct transcriptional activation of CerS6, p53 can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.

  4. silencing of CerS6 induced the increased expression of GLUT1, which downregulated the expression of WNT5A and enhanced the invasion and proliferation of melanoma cells.

  5. Identification of CerS6 and ceramide pathways as a novel Methotrexate target.

  6. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  7. stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6/p38 kinase in lipid rafts

  8. CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.

  9. Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.

  10. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction.

  11. Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase in a JNK-dependent manner that is independent of CerS6 activity.

  12. CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.

  13. Upregulation of CERS6 in an experimental autoimmune encephalomyelitis model is sex dependent.

  14. Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  15. folate withdrawal also induced CerS6/C16-ceramide elevation accompanied by p53 accumulation. Overall, these novel findings link folate and de novo ceramide pathways in cellular stress response.

  16. The transiently increased expression of ceramide synthase (CerS6) correlates to the clinical finding that C(16:0)-Cer levels are increased 1.9-fold in cerebrospinal fluid of multiple sclerosis patients.

  17. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network

  18. ionizing radiation induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes.

  19. CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA.

  20. Findings indicate that mda-7/IL-24 induces PERK activation that triggers production of ceramide, ceramide synthase 6 and thioredoxin, which in turn promote glioma cell autophagy and cell death.

Mouse (Murine) Ceramide Synthase 6 (CERS6) interaction partners

  1. ceramide synthase (CerS)6 was specifically up-regulated in experimental alcoholic steatosis in vivo and in vitro

  2. CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.

  3. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  4. CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.

  5. Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.

  6. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.

  7. CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.

  8. An important role is revealed for C16:0-Cer (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.

  9. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network

Ceramide Synthase 6 (CERS6) Protein Profile

Protein Summary

May be involved in sphingolipid synthesis or its regulation (By similarity).

Gene names and symbols associated with Ceramide Synthase 6 Proteins (CERS6)

  • ceramide synthase 6 (CERS6)
  • ceramide synthase 6 (cers6)
  • ceramide synthase 6 (Cers6)
  • 4732462C07Rik protein
  • AW544719 protein
  • CERS5 protein
  • CERS6 protein
  • Lass6 protein
  • RGD1561599 protein
  • si:ch211-278b7.1 protein
  • T1L protein

Protein level used designations for Ceramide Synthase 6 Proteins (CERS6)

LAG1 homolog, ceramide synthase 6 , lass6 , longevity assurance homolog 6 , LAG1 longevity assurance homolog 6

GENE ID SPECIES
100052305 Equus caballus
564867 Danio rerio
741293 Pan troglodytes
253782 Homo sapiens
241447 Mus musculus
366065 Rattus norvegicus
771503 Gallus gallus
488387 Canis lupus familiaris
100126279 Sus scrofa
616901 Bos taurus
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