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May be involved in sphingolipid synthesis or its regulation (By similarity)..
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This study has shown that by direct transcriptional activation of CerS6, p53 (show TP53 Proteins) can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.
silencing of CerS6 induced the increased expression of GLUT1 (show SLC2A1 Proteins), which downregulated the expression of WNT5A (show WNT5A Proteins) and enhanced the invasion and proliferation of melanoma cells.
Identification of CerS6 and ceramide pathways as a novel Methotrexate target.
stichoposide D inhibits growth of experimental leukemia by activating Fas (show FAS Proteins)/ceramide synthase 6/p38 (show CRK Proteins) kinase in lipid rafts
CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.
Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.
On the basis of its pivotal role in regulating cell death upon COX (show COX8A Proteins) dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX (show COX8A Proteins) dysfunction.
Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase (show ASAH1 Proteins) in a JNK (show MAPK8 Proteins)-dependent manner that is independent of CerS6 activity.
CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.
Upregulation of CERS6 in an experimental autoimmune encephalomyelitis model is sex dependent.
CerS1 (show CERS1 Proteins), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Proteins)-null mice.
CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.
Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Proteins)-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.
An important role is revealed for C16:0-Cer (show CBLN1 Proteins) (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6 (show ATF6 Proteins)-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2 (show CA2 Proteins)+ and ER/Golgi membrane network
May be involved in sphingolipid synthesis or its regulation (By similarity).
LAG1 homolog, ceramide synthase 6
, longevity assurance homolog 6
, LAG1 longevity assurance homolog 6