Chromosome 1 Open Reading Frame 84 Proteins (C1orf84)

The protein encoded by C1orf84 is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. Additionally we are shipping Chromosome 1 Open Reading Frame 84 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C1orf84 23334 Q5T011
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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C1orf84 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Chromosome 1 Open Reading Frame 84 (C1orf84) Interaction Partners

Human Chromosome 1 Open Reading Frame 84 (C1orf84) interaction partners

  1. identification of a protein complex (KICSTOR) that is composed of four proteins, KPTN (show KPTN Proteins), ITFG2, C12orf66 and SZT2, and that is required for amino acid or glucose deprivation to inhibit mTORC1 in cultured human cells

  2. SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment

  3. We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures.

  4. mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy.

Chromosome 1 Open Reading Frame 84 (C1orf84) Protein Profile

Protein Summary

The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis.

Gene names and symbols associated with C1orf84

  • SZT2, KICSTOR complex subunit (SZT2)
  • C1orf84 protein
  • KIAA0467 protein
  • RP11-506B15.3 protein
  • SZT2A protein
  • SZT2B protein

Protein level used designations for C1orf84

protein SZT2 , seizure threshold 2 protein homolog

GENE ID SPECIES
23334 Homo sapiens
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