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Plays a role in the trafficking of mitochondria along microtubules.
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The ratio of motile mitochondria was remarkably decreased in the axons of MGARP-overexpressing cells.
These results indicate that HUMMR does not play a key role in mitochondrial dysfunction in the APP (show APP Proteins)/PS1 (show PSEN1 Proteins) double transgenic Alzheimer disease mouse
MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the hypothalamic-pituitary-gonadal axis.
Results identify a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina [MGARP].
HUMMR (Hypoxia Upregulated Mitochondrial Movement Regulator) is induced by HIF-1 and regulates mitochondrial distribution and movement in neurons during hypoxia
OSAP is prominently expressed in steroidogenic tissues; results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology
The present study identified a proximal core sequence in the MGARP promoter that is composed of two enriched Sp1 (show PSG1 Proteins) binding motifs and established Sp1 (show PSG1 Proteins) as one major MGARP transactivator.
Results identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha (show HIF1A Proteins)).
Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).
corneal endothelium-specific protein 1
, hypoxia up-regulated mitochondrial movement regulator protein
, mitochondria-localized glutamic acid-rich protein
, ovary-specific acidic protein
, protein MGARP
, hypoxia up-regulated mitochondrial movement regulator