anti-Crystallin, gamma S (CRYGS) Antibodies

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYGS Proteins (14) and CRYGS Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRYGS 12970 O35486
CRYGS 689897 P0C5E9
CRYGS 1427 P22914
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Top anti-CRYGS Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Crygs Antibody Dilution: 1.0ug/ml Sample Type: Rat Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Crygs Antibody Dilution: 1.0ug/ml Sample Type: Rat Testis 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB CRYGS Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35µg/lane).This demonstrates the CRYGS antibody detected the CRYGS protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB CRYGS Antibody (C-term) (ABIN654694) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the CRYGS antibody detected the CRYGS protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of mouse eye and rat eye, using CRYGS antibody. 100 μL Log in to see 16 Days
$334.77
Details
Rat Rabbit Un-conjugated WB Western Blot: CRYGS Antibody [NBP1-98420] - Antibody Dilution: 1.0ug/ml Sample Tissue: Rat Stomach. 100 μL Log in to see 8 to 11 Days
$485.88
Details
Human Mouse Un-conjugated WB Western Blot analysis of CRYGS expression in transfected 293T cell line by CRYGS MaxPab polyclonal antibody.Lane 1: CRYGS transfected lysate(19.58 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$354.20
Details
Cow Rabbit Un-conjugated WB   50 μg Log in to see 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB   50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using CRYGS antibody. 120 μL Log in to see 12 to 14 Days
$251.90
Details

More Antibodies against CRYGS Interaction Partners

Mouse (Murine) Crystallin, gamma S (CRYGS) interaction partners

  1. gammaS may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation

  2. Mutant Crygs gene can lead to changes of BFSP/filensin (show BFSP1 Antibodies) and other crystallins. Changes to these crystallins, together, may secondarily lead to cataract formation.

  3. disruption of the Hsf4 (show HSF4 Antibodies) gene leads to cataracts via at least three pathways: down-regulation of gamma-crystallin, particularly gamma S-crystallin; decreased lens beaded filament expression; and loss of post-translational modification of alpha A-crystallin (show CRYAA Antibodies)

Cow (Bovine) Crystallin, gamma S (CRYGS) interaction partners

  1. Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin (show CRYAA Antibodies), betaB2- and gammaS-(betaS)-crystallins.

Human Crystallin, gamma S (CRYGS) interaction partners

  1. aberrant modifications in gammaS-crystallin structure might contribute to the lower stability and higher aggregatory potency of the mutated protein, which subsequently resulted in cataracts in the patients

  2. The Tyr67Asn substitution was predicted to decrease the local hydrophobicity and affect the three-dimensional structure of gammaS-crystallin, and resulted in a portion of mutant protein translocation from the cytoplasm to cell membrane. This observations expand the mutation spectrum of CRYGS and provide further evidence for the genetic basis and molecular mechanism of congenital cataract.

  3. Cataract-related G18V point mutation affects CRYGS stability and hydration.

  4. novel mutation (G57W) in CRYGS in this Chinese family is associated with autosomal dominant pulverulent cataract.

  5. The data suggest that enhanced attractive protein-protein interactions, arising from the deamidation of HGS, promote protein aggregation, thereby leading to increased light scattering and opacity over time.

  6. The effects of the V41M mutation on the structural changes of gamma S-crystallin were studied.

  7. The cataract-associated mutant D26G of human gammaS-crystallin is remarkably close to the wild type molecule in structural features, with only a microenvironmental change in the packing around the mutation site.

  8. replacement of valine in position 42 by the longer and bulkier methionine in human gammaS-crystallin perturbs the compact beta-sheet core packing topology in the N-terminal domain of the molecule

  9. age-dependent cleavage of gammaS-crystallin generates a peptide that binds to cell membranes

  10. Molecular dynamics (MD) simulations, circular dichroism (CD), and dynamic light scattering (DLS) measurements were used to investigate the aggregation propensity of the eye-lens protein gammaS-crystallin.

CRYGS Antigen Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Gene names and symbols associated with CRYGS

  • crystallin, gamma S (Crygs) antibody
  • crystallin gamma S (CRYGS) antibody
  • crystallin gamma S (Crygs) antibody
  • AI327013 antibody
  • CRYG8 antibody
  • CTRCT20 antibody
  • Opj antibody
  • rncat antibody

Protein level used designations for CRYGS

beta-crystallin S , opacity due to poor secondary fiber cell junction , recessive nuclear cataract , crystallin, gamma polypeptide 8 , gamma-S-crystallin , gamma-crystallin S , gamma S-crystallin , crystallin, gamma S , gammaS-crystallin , crystallin, gamma 8

GENE ID SPECIES
12970 Mus musculus
281724 Bos taurus
429134 Gallus gallus
460909 Pan troglodytes
689897 Rattus norvegicus
699720 Macaca mulatta
100101573 Oryctolagus cuniculus
100307056 Cavia porcellus
1427 Homo sapiens
607506 Canis lupus familiaris
100155317 Sus scrofa
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