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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.
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Human Polyclonal DDX41 Primary Antibody for WB - ABIN1881255
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
Show all 3 Pubmed References
Human Monoclonal DDX41 Primary Antibody for IF, ELISA - ABIN565608
Omura, Oikawa, Nakane, Kato, Ishii, Ishitani, Tokunaga, Nureki: Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. in Scientific reports 2016
Cow (Bovine) Polyclonal DDX41 Primary Antibody for WB - ABIN2775230
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Results show that the DDX41 DEAD domain recognizes both double-stranded DNA (dsDNA) and cyclic dinucleotides (CDN (show NT5C Antibodies)) at the same binding site. A structural comparison between the open and closed forms of the DDX41 DEAD domain revealed the structural rearrangement in the N-terminal region, which drastically changes the conformation of the ATP-binding site.
analysis suggests that rather than establishing a causal Mendelian link between DDX41 germline LOF variants and MDS (show PAFAH1B1 Antibodies)/AML (show RUNX1 Antibodies) it is appropriate to consider these as genetic risk factors
Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia (show BCL11A Antibodies).
Structural and functional analyses of human DDX41 DEAD domain.
DDX41 mutations lead to development of high-risk myelodysplastic syndrome.(review)
An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (show BCL11A Antibodies) (MDS (show PAFAH1B1 Antibodies)/AML (show RUNX1 Antibodies)) patients.
data demonstrate that DDX41 suppresses p21 (show CDKN1A Antibodies) translation without disturbing the function of p53 (show TP53 Antibodies) to directly induce p21 (show CDKN1A Antibodies) mRNA expression, this process indirectly requires p53 (show TP53 Antibodies), perhaps in the form of another p53 (show TP53 Antibodies) target gene or as a still undefined posttranscriptional function of p53 (show TP53 Antibodies).
This study uncovered a pathogenic role of p.R525H DDX41 in the slow growth rate of tumor cells. Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML (show RUNX1 Antibodies).
This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations.
corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK (show BTK Antibodies) phosphorylation site.
TRIM21 (show TRIM21 Antibodies) is an interferon (show IFNA Antibodies)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.
DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
, DEAD-box protein abstrakt
, probable ATP-dependent RNA helicase DDX41-like
, DEAD box protein 41
, DEAD box protein abstrakt homolog
, probable ATP-dependent RNA helicase DDX41
, putative RNA helicase