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DNASE2 encodes a member of the DNase family.
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These results confirm that DNase II and the ability to clear macromolecular DNA is essential for maintaining proper immune function in Drosophila.
findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.
holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation
Data show that Klf1 (show KLF1 Proteins) is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a.
Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1 (show DNASE1 Proteins), DNASE1L3 (show DNASE1L3 Proteins), and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.
15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique.
study demonstrated the relationship of genotypes/haplotypes with the in vivo DNase II and promoter activities; significant correlations between genotype in each rheumatoid arthritis (RA)-related SNP and enzymatic activity levels were found; alleles associated with RA exhibited a reduction in serum DNase II activity.
upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells
Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells.
the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold
The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease.
Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation
Data showed an association between PARP-1 and LEI/L-DNase II.
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
, acid DNase
, deoxyribonuclease 1
, deoxyribonuclease II, lysosomal
, DNase II alpha
, lysosomal DNase II
, DNase II, lysosomal
, deoxyribonuclease II alpha