Deoxyribonuclease II, Lysosomal Proteins (DNASE2)

DNASE2 encodes a member of the DNase family. Additionally we are shipping Deoxyribonuclease II, Lysosomal Antibodies (53) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNASE2 13423 P56542
DNASE2 1777 O00115
DNASE2 171575 Q9QZK8
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top Deoxyribonuclease II, Lysosomal Proteins at

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days

DNASE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

More Proteins for Deoxyribonuclease II, Lysosomal (DNASE2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. These results confirm that DNase II and the ability to clear macromolecular DNA is essential for maintaining proper immune function in Drosophila.

  2. findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.

Mouse (Murine) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation

  2. Data show that Klf1 (show KLF1 Proteins) is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a.

Human Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. Study identifies biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity causing type I interferonopathy in three patients from two unrelated families.

  2. Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1 (show DNASE1 Proteins), DNASE1L3 (show DNASE1L3 Proteins), and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.

  3. 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique.

  4. study demonstrated the relationship of genotypes/haplotypes with the in vivo DNase II and promoter activities; significant correlations between genotype in each rheumatoid arthritis (RA)-related SNP and enzymatic activity levels were found; alleles associated with RA exhibited a reduction in serum DNase II activity.

  5. upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells

  6. Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells.

  7. the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold

  8. The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease.

Pig (Porcine) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation

  2. Data showed an association between PARP-1 and LEI/L-DNase II.

Deoxyribonuclease II, Lysosomal (DNASE2) Protein Profile

Protein Summary

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

Gene names and symbols associated with DNASE2

  • Deoxyribonuclease II (DNaseII)
  • deoxyribonuclease II, lysosomal L homeolog (dnase2.L)
  • deoxyribonuclease 2, lysosomal (DNASE2)
  • deoxyribonuclease II, lysosomal (dnase2)
  • deoxyribonuclease II (dnase2)
  • deoxyribonuclease II alpha (Dnase2a)
  • deoxyribonuclease 2, lysosomal (Dnase2)
  • CG7780 protein
  • DDBDRAFT_0188966 protein
  • DDBDRAFT_0252883 protein
  • DDB_0188966 protein
  • DDB_0252883 protein
  • dDNase II protein
  • Dmel\\CG7780 protein
  • DNase protein
  • DNase-1 protein
  • DNase1 protein
  • DNase 1 protein
  • Dnase2 protein
  • Dnase2a protein
  • DNL protein
  • DNL2 protein
  • fa92d01 protein
  • LOC733868 protein
  • MGC80103 protein
  • wu:fa56d08 protein
  • wu:fa92d01 protein

Protein level used designations for DNASE2

deoxyribonuclease II , CG7780-PA , DNaseII-PA , acid DNase , deoxyribonuclease 1 , deoxyribonuclease II, lysosomal , deoxyribonuclease-2-alpha , fa56d08 , DNase II alpha , lysosomal DNase II , DNase II, lysosomal , R31240_2 , deoxyribonuclease II alpha

48228 Drosophila melanogaster
446506 Xenopus laevis
476697 Canis lupus familiaris
733868 Xenopus (Silurana) tropicalis
747576 Pan troglodytes
100000399 Danio rerio
100171654 Pongo abelii
100599185 Nomascus leucogenys
8627734 Dictyostelium discoideum AX4
13423 Mus musculus
1777 Homo sapiens
171575 Rattus norvegicus
282218 Bos taurus
397398 Sus scrofa
Selected quality suppliers for Deoxyribonuclease II, Lysosomal Proteins (DNASE2)
Did you look for something else?