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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Antibodies (110) and DUSP1 Kits (29) and many more products for this protein.
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Curcumin suppressed CXCL5 (show CXCL5 Proteins) expression by direct inhibition of IKKbeta (show IKBKB Proteins) phosphorylation, and inhibition of p38 MAPK (show MAPK14 Proteins) via induction of negative regulator MKP-1.
MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review)
We propose a signaling cascade involving ARID1A, GADD45B (show GADD45B Proteins) and DUSP1 as mediators of the romidepsin effects in GCC (show GUCY2C Proteins) cells.
this work indicates that suppression of JNK1 (show MAPK8 Proteins)/2 activity by MKP-1 maintains PARP-1 (show PARP1 Proteins) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (show PARP1 Proteins) inhibition.
Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.
Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.
Increased MAP2K6 (show MAP2K6 Proteins), MAP4K3 (show MAP4K3 Proteins), and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (show PPP2R4 Proteins), CDC25 (show RASGRF1 Proteins) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.
The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.
FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling.
these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic
MKP-1 regulates IL-1beta (show IL1B Proteins) production through stabilization of HIF-1alpha (show HIF1A Proteins). The induction of HIF-1alpha (show HIF1A Proteins) protein in MKP-1 deficiency is partly due to p38MAPK (show MAPK14 Proteins) activation in response to LPS (show TLR4 Proteins).
this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.
c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 Proteins) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.
PTHrP counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (show ADORA2A Proteins) signaling regulates both basal and LPS (show TLR4 Proteins)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Proteins) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (show NR4A1 Proteins) induction is dependent on ERK1/2 and that MKP-1 negatively regulates this induction.
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN Proteins) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 Proteins) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1