Dual Specificity Phosphatase 1 Proteins (DUSP1)

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Antibodies (131) and DUSP1 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUSP1 1843 P28562
DUSP1 114856 Q64623
DUSP1 19252 P28563
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Top DUSP1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days

DUSP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Dual Specificity Phosphatase 1 (DUSP1) Interaction Partners

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. SIN (show EFS Proteins) attenuated LPS (show IRF6 Proteins)-induced inflammatory injury by regulation of miR (show MLXIP Proteins)-101, MKP-1 and JNK (show MAPK8 Proteins) pathway.

  2. miR (show MLXIP Proteins)-202-3p is upregulated in type 1 gastric neuroendocrine neoplasms (g-NENs) lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1.

  3. Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2.

  4. the expression of DUSP1 was lower in OA FLSs than in normal FLSs, and DUSP1 may inhibit the expression of OA-associated mediators, MMP-13 (show MMP13 Proteins) and COX-2, by suppressing the activation of p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) pathways in OA FLSs.

  5. Curcumin suppressed CXCL5 (show CXCL5 Proteins) expression by direct inhibition of IKKbeta (show IKBKB Proteins) phosphorylation, and inhibition of p38 MAPK (show MAPK14 Proteins) via induction of negative regulator MKP-1.

  6. MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review)

  7. We propose a signaling cascade involving ARID1A, GADD45B (show GADD45B Proteins) and DUSP1 as mediators of the romidepsin effects in GCC (show GUCY2C Proteins) cells.

  8. this work indicates that suppression of JNK1 (show MAPK8 Proteins)/2 activity by MKP-1 maintains PARP-1 (show PARP1 Proteins) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (show PARP1 Proteins) inhibition.

  9. Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.

  10. Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Low DUSP1 expression is associated with cerebral ischaemia reperfusion injury.

  2. Results indicate that the upregulation of anterior cingulate cortex (ACC, areas 24a and 24b) MKP-1 is necessary for the expression of depressive symptoms induced by chronic pain, chronic stress, and optogenetic activation of the ACC.

  3. The results suggested that DUSP1 gene silencing promoted the release of proinflammatory cytokines through activation of the MAPK (show MAPK1 Proteins) signaling pathway in mice with acute pancreatitis.

  4. The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK (show MAPK8 Proteins) which upregulated the expression of the mitochondrial fission factor (Mff (show MFF Proteins)).

  5. Study demonstrates that MKP-1 serves as a master-regulator of macrophage phenotype and function and its dysregulation by metabolic stress may be a major contributor to atherogenesis and the progression of atherosclerotic plaques.

  6. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling.

  7. these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic

  8. MKP-1 regulates IL-1beta (show IL1B Proteins) production through stabilization of HIF-1alpha (show HIF1A Proteins). The induction of HIF-1alpha (show HIF1A Proteins) protein in MKP-1 deficiency is partly due to p38MAPK (show MAPK14 Proteins) activation in response to LPS (show TLR4 Proteins).

  9. this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.

  10. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 Proteins) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.

Pig (Porcine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC (show FYN Proteins) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 Proteins) activity at submaximal values.

DUSP1 Protein Profile

Protein Summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1)
  • dual specificity phosphatase 1 (Dusp1)
  • dual specificity phosphatase 1 (dusp1)
  • dual specificity phosphatase 1 S homeolog (dusp1.S)
  • 3CH134 protein
  • cb269 protein
  • CL100 protein
  • DUSP1 protein
  • erp protein
  • HVH1 protein
  • id:ibd2586 protein
  • mkp-1 protein
  • Mkp1 protein
  • PTPN10 protein
  • Ptpn16 protein
  • sb:cb269 protein
  • U19515 protein
  • wu:fd19g02 protein
  • wu:fe50g09 protein
  • XCL100 protein
  • zgc:55920 protein

Protein level used designations for DUSP1

MAP kinase phosphatase 1 , dual specificity protein phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , dual specificity phosphatase 1 , mitogen-activated protein kinase phosphatase-1 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , mkp-1 , MAPK phosphatase 1 , LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 , MAP kinase phosphatase XCL100(beta) protein , XCL100-beta , dual specificity protein phosphatase 1-B , dusp1-b

1843 Homo sapiens
114856 Rattus norvegicus
374192 Gallus gallus
471742 Pan troglodytes
539175 Bos taurus
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
19252 Mus musculus
406340 Danio rerio
100522469 Sus scrofa
489117 Canis lupus familiaris
100725668 Cavia porcellus
398254 Xenopus laevis
101107632 Ovis aries musimon
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