Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids.
Showing 3 out of 3 products:
Elovl1 is a key determinant of epidermal ceramide chain length and is essential for permeability barrier formation.
ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil.
Results suggest that inhibition of atty acid elongase 1 (ELOVL1) may be an underlying mechanism by which Lorenzo's oil exerts its action.
down-regulation of ELOVL1 had a comprehensive effect on the synthesis of very long chain ceramides which possibly point to a requirement for ELOVL1 expression for full CerS2 (show CERS2 Proteins)-activity.
ELOVL1 activity is regulated with the ceramide synthase CERS2 (show CERS2 Proteins), an enzyme essential for C24 sphingolipid synthesis.
The authors identify ELOVL1 (elongation of very-long-chain-fatty acids) as the single elongase catalysing the synthesis of both saturated VLCFA (C26:0) and mono-unsaturated VLCFA (C26:1).
Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis.
3-keto acyl-CoA synthase Elovl1
, ELOVL FA elongase 1
, ELOVL fatty acid elongase 1
, elongation of very long chain fatty acids protein 1
, elongation of very long chain fatty acids-like 1
, sequence similarity to Cig30 1
, very-long-chain 3-oxoacyl-CoA synthase 1
, 3-keto acyl-CoA synthase ELOVL1
, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1