Endogenous Retrovirus Group W, Member 1 Proteins (ERVW-1)

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. Additionally we are shipping ERVW-1 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERVW-1 30816 Q9UQF0
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Top ERVW-1 Proteins at antibodies-online.com

Showing 2 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

ERVW-1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,

Top referenced ERVW-1 Proteins

  1. Human ERVW-1 Protein expressed in Wheat germ - ABIN1353105 : Holder, Tower, Forbes, Mulla, Aplin, Abrahams: Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1. in Immunology 2012 (PubMed)

More Proteins for Endogenous Retrovirus Group W, Member 1 (ERVW-1) Interaction Partners

Human Endogenous Retrovirus Group W, Member 1 (ERVW-1) interaction partners

  1. CD47 (show CD47 Proteins) seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure.

  2. ERVWE1, ERVFRDE1 and ERV3 (show ERV3-1 Proteins) transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.

  3. Study found no associations between embroynal ERVW-1 polymorphisms and preeclampsia.

  4. Identification of the two CpG dinucleotides around transcription start site as key epigenetic elements has provided valuable information for further studies on the epigenetic regulation of syncytin-1 in pancreatic cancer cells

  5. Syncytin-1 and ASCT-2 (show SLC1A5 Proteins) is localized at the acrosomal region and equatorial segment of the spermatozoa.

  6. The effect of ETS1 (show ETS1 Proteins) on syncytialization of trophoblasts likely results, at least in part, from inhibition of syncytin expression.

  7. These results indicated that aberrant hypermethylation is involved in downregulation of syncytin-1, and epigenetic alterations may play a significant role in the development of preeclampsia

  8. Exosomes from cultured primary villous cytotrophoblasts and sera of pregnant women have syncytin-1 on their surfaces. It acts on cellular binding and uptake of exosomes.

  9. Increased trophoblast apoptosis and altered expression levels of syncytin-1, calpain 1 (show CAPN1 Proteins), and AIF (show AIFM1 Proteins) is observed in preeclamptic placentas.

  10. Syncytin-1 overexpression may be an indicator of urothelial cell carcinoma risk.

ERVW-1 Protein Profile

Protein Summary

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with ERVW-1

  • endogenous retrovirus group W member 1, envelope (ERVW-1)
  • ENV protein
  • ENVW protein
  • ERVWE1 protein
  • HERV-7q protein
  • HERV-W-ENV protein
  • HERV7Q protein
  • HERVW protein
  • HERVWENV protein

Protein level used designations for ERVW-1

HERV-7q envelope protein , HERV-W Env glycoprotein , HERV-W envelope protein , HERV-W_7q21.2 provirus ancestral Env polyprotein , HERV-W{7q21.1} provirus ancestral Env polyprotein , HERV-tryptophan envelope protein , endogenous retroviral family W, env(C7), member 1 , endogenous retrovirus group W member 1 , env-W , envelope glycoprotein , envelope polyprotein gPr73 , envelope protein , enverin , human endogenous retrovirus W envC7-1 envelope protein , syncytin A , syncytin-1

GENE ID SPECIES
30816 Homo sapiens
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