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Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Additionally we are shipping Endoplasmic Reticulum To Nucleus Signaling 2 Proteins (6) and Endoplasmic Reticulum To Nucleus Signaling 2 Kits (3) and many more products for this protein.
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Human Polyclonal ERN2 Primary Antibody for ELISA - ABIN449712
Brewer, Diehl: PERK mediates cell-cycle exit during the mammalian unfolded protein response. in Proceedings of the National Academy of Sciences of the United States of America 2000
Data show that LPS (show TLR4 Antibodies) induces endoplasmic reticulum (ER) stress and P300 (show NOTCH1 Antibodies) activity via the XBP1 (show XBP1 Antibodies)/IRE1 (show ERN1 Antibodies) pathway.
Regulated IRE1 (show ERN1 Antibodies)-dependent mRNA decay sets the threshold for dendritic cell survival.
Data show that EIF2AK3/PERK (show EIF2AK3 Antibodies)-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Antibodies) protein and activating transcription factor 6 (ATF6 (show ATF6 Antibodies)) during conditions of endoplasmic reticulum stress.
Our results reveal a role for IRE1 (show ERN1 Antibodies) in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.
Our data indicate that removal of XBP-1 (show XBP1 Antibodies) confers a kinetic delay in early stages of MCMV infection and suggest that the late targeting of IRE1 (show ERN1 Antibodies) is aimed at inhibiting activities other than the splicing of XBP-1 (show XBP1 Antibodies) mRNA
ER stress accentuated CVB3-induced myocardial inflammation through the IRE1 (show ERN1 Antibodies)-associated NF-kappaB (show NFKB1 Antibodies) pathway.
This study provides the first in vivo evidence that PP2Ce is an essential regulator of normal lactation, possibly involving IRE1 (show ERN1 Antibodies) signaling and endoplasmic reticulum stress regulation in mammary epithelium.
suggest that activation of IRE1 (show ERN1 Antibodies)-JNK (show MAPK8 Antibodies) pathway is a key linker of impaired hepatic insulin (show INS Antibodies) signaling transduction induced by HFru feeding
Regulated IRE1 (show ERN1 Antibodies)-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.
Regulated IRE1 (show ERN1 Antibodies)-dependent decay pathway is activated during Japanese encephalitis virus and benefits viral replication.
ER stress-regulated IRE1 (show ERN1 Antibodies) dependent decay is involved in regulation of hepatic diseases. (review)
The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP (show GDF10 Antibodies).
Data show that IRE1beta represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1beta.
The structural, biochemical, and functional studies in vivo altogether demonstrate that IRE1 and PERK have conserved a common molecular interface necessary and sufficient for dimerization and unfolded protein response (UPR) signaling.
RNase domain of IRE1 (show ERN1 Antibodies) determines the functional specificities of each of these isoforms.
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
endoplasmic reticulum to nucleus signaling 2
, endoplasmic reticulum to nucleus signalling 2
, endoplasmic reticulum (ER) to nucleus signalling 2
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, ER to nucleus signalling 2
, IRE1 beta
, IRE1, S. cerevisiae, homolog of