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Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Additionally we are shipping Endoplasmic Reticulum To Nucleus Signaling 2 Proteins (8) and Endoplasmic Reticulum To Nucleus Signaling 2 Kits (5) and many more products for this protein.
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Human Polyclonal ERN2 Primary Antibody for ELISA - ABIN543637
Wang, Harding, Zhang, Jolicoeur, Kuroda, Ron: Cloning of mammalian Ire1 reveals diversity in the ER stress responses. in The EMBO journal 1998
Show all 3 Pubmed References
Polyclonal ERN2 Primary Antibody for ELISA, WB - ABIN539764
Brewer, Diehl: PERK mediates cell-cycle exit during the mammalian unfolded protein response. in Proceedings of the National Academy of Sciences of the United States of America 2000
ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review)
The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP.
Data show that IRE1beta represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1beta.
The structural, biochemical, and functional studies in vivo altogether demonstrate that IRE1 and PERK have conserved a common molecular interface necessary and sufficient for dimerization and unfolded protein response (UPR) signaling.
RNase domain of IRE1 determines the functional specificities of each of these isoforms.
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
endoplasmic reticulum to nucleus signaling 2
, endoplasmic reticulum to nucleus signalling 2
, endoplasmic reticulum (ER) to nucleus signalling 2
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, ER to nucleus signalling 2
, IRE1 beta
, IRE1, S. cerevisiae, homolog of