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EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008].. Additionally we are shipping EDC3 Antibodies (55) and many more products for this protein.
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The modular architecture enables enhancer of decapping 3 (EDC3) to interact with multiple components of the decapping (show ACE Proteins) machi (show DCP2 Proteins)nery, inclu (show DDX6 Proteins)ding DCP1, DCP2, and Me31B.
Tral (show LSM14A Proteins) and EDC3 specifically interact with the decapping activator DCP1 (show ACE Proteins) and the DEAD-box helicase Me31B (show DDX6 Proteins), in Drosophila cells.
In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 (show DCP2 Proteins) decapping at low concentrations and even inhibits DCP2 (show DCP2 Proteins) decapping at high concentration.
The modular architecture enables EDC3 to interact with multiple components of the decapping machinery, including DCP1 (show ACE Proteins), DCP2 (show DCP2 Proteins), and Me31B (show DDX6 Proteins).
The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral (show LSM14A Proteins) to the DEAD box protein (show INTS6 Proteins) DDX6/Me31B (show DDX6 Proteins).
Induction of 14-3-3 (show YWHAQ Proteins) binding to EDC3 causes morphological changes in processing body structures, inhibition of microRNA-mediated mRNA post-transcriptional regulation, and alterations in the protein- protein interactions of EDC3.
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005
LSM16 homolog (EDC3, S. cerevisiae)
, enhancer of decapping 3
, enhancer of decapping-3
, enhancer of mRNA decapping 3 homolog
, enhancer of mRNA-decapping protein 3
, yjeF domain-containing protein 1
, yjeF N-terminal domain-containing protein 2
, yjeF domain containing
, LSM16 protein homolog