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mRNA-binding protein involved in translation elongation. Additionally we are shipping EIF5A2 Antibodies (81) and EIF5A2 Kits (2) and many more products for this protein.
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EIF5A2 as a direct and functional target of miR (show MLXIP Proteins)-203.
The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 (show NCOA3 Proteins) and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1 (show NCOA3 Proteins), EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
Data suggest that inhibition of eIF5A2 alters progression of the EMT (show ITK Proteins) to decrease the invasion and metastasis of HCC (show FAM126A Proteins) cells via ROS (show ROS1 Proteins)-related pathways.
EIF5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF5A2 could be a novel potential prognostic marker for Federation of Gynecology and Obstetrics (FIGO) stage I-II cervical cancer.
High EIF5A2 expression is associated with hepatocellular carcinoma.
MiR (show MLXIP Proteins)-30b suppresses tumor migration and invasion by targeting EIF5A2 expression in gastric cancer cells.
eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells.
Data indicate that regulation of sonic hedgehog (SHh (show SHH Proteins))-GLI family zinc finger 1 (Gli1 (show GLI1 Proteins)) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression.
Data suggest that eukaryotic translation initiation factor 5A2 (EIF5A2) inhibitors might be considered as combination therapy to enhance chemosensitivity in patients with esophageal squamous cell carcinoma (ESCC).
Our findings indicate that EIF5A2 upregulation plays an important oncogenic role in gastric cancer. EIF5A2 may represent a new predictor for poor survival and is a potential therapeutic target for gastric cancer.
activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
Eukaryotic initiation factor 5A (eIF5A) (eIF-4D (show EIF5A Proteins), eIF-5A (show EIF5A Proteins)) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys (show LYZ Proteins) 50. Mouse EIF5A1 (show EIF5A Proteins) and EIF5A2 encode two isoforms: eIF5AI (show EIF5A Proteins) and eIF5AII.
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
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