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FOXRED1 encodes a protein that contains a FAD-dependent oxidoreductase domain. Additionally we are shipping FAD-Dependent Oxidoreductase Domain Containing 1 Antibodies (40) and many more products for this protein.
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Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1 (show MT-ND1 Proteins)-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I.
Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I.
A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site.
FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis.
Mutations in FOXRED1 are associated with complex I deficiency.
This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene.
FAD-dependent oxidoreductase domain-containing protein 1
, testis expressed gene 23