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The Fos gene family consists of 4 members FOSL1, and FOSL2. Additionally we are shipping FBJ Murine Osteosarcoma Viral Oncogene Homolog B Antibodies (93) and FBJ Murine Osteosarcoma Viral Oncogene Homolog B Kits (5) and many more products for this protein.
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FOSB overexpression results in TNBC cell death, whereas inhibition of calcium signaling eliminates FOSB induction and blocks TP4-induced TNBC cell death
results shows the involvement of Spry2 (show SPRY2 Proteins) in regulation of FosB and Runx2 (show RUNX2 Proteins) genes, MAPK (show MAPK1 Proteins) signaling and proliferation of mesenchymal stem cells.
the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins.
The NFATc3 (show NFATC3 Proteins) first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3 (show NFATC3 Proteins)-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression.
FosB expression in the prefrontal cortex and hippocampus of the cocaine addicted and depression patients
FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma.
our findings show that DeltaFosB increases the expression of MMP-9 (show MMP9 Proteins) and exhibits a significantly high survival and proliferation in MCF-7 cells.
Diffuse and strong FOSB expression was specific for pseudomyogenic hemangioendothelioma in the current series and FOSB immunohistochemistry is an effective tool for differentiating between PHE and its histological mimics.
Our results using a number of approaches, such as promoter reporter assay, FosB knock down and Chip assay, suggest that the expression of miR (show MLXIP Proteins)-22 is regulated transcriptionally by FosB.
These results suggest that SETDB1 (show SETDB1 Proteins)- mediated FosB expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.
These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARgamma (show PPARG Proteins) in mouse mammary glands.
propose that chronic suppression of calbindin (show CALB1 Proteins) by DeltaFosB is one mechanism through which intermittent seizures drive persistent cognitive deficits in conditions accompanied by recurrent seizures
Both CREB (show CREB1 Proteins) and deltaFosB play a role in the induction of this behavioural sensitization.
Study investigated effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts and mapped the CVMS-related FosB response in 18 brain areas; found that PACAP (show ADCYAP1 Proteins) deficiency affects neuronal reactivity in a brain area-specific manner in stress centers
abnormal regulation of MSK1 (show RPS6KA5 Proteins) contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 (show HIST3H3 Proteins) phosphorylation at the fosB promoter
The most highly stereotypic mice showed the most elevated FosB/DeltaFosB activity in the nucleus accumbens
FosB/DeltaFosB immunoreactivity was transiently increased in hippocampus and parahippocampal cortices by 6-Hz corneal stimulation. FosB induction was primarily localized in pyramidal neurons.
Histone methylation or acetylation at the Fosb locus in nucleus accumbens, was sufficient to control drug- and stress-evoked behavioral responses.
Findings demonstrate that, under excitotoxicity, Fosb products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 (show C5AR1 Proteins) and C5ar2 expression
These results indicate that social stress-induced behavioral deficits are mediated partly by molecular adaptations in mPFC involving DeltaFosB and CCK (show CCK Proteins) through cortical projections to distinct subcortical targets.
The Fos gene family consists of 4 members FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
FBJ murine osteosarcoma viral oncogene homolog B
, protein fosB
, G0/G1 switch regulatory protein 3
, activator protein 1
, FBJ osteosarcoma viral oncogene isoform deltaFosb-2