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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (143) and FTO Kits (9) and many more products for this protein.
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The aggregation analysis revealed a higher correlation between siblings than between parent-offspring pairs representing the role of genetic factors in metabolic syndrome (MetS (show ETV3 Proteins)). In addition, the conditional logistic model with covariates showed that the linkage results between HDL_C and three markers, FTO (rs1558902 and rs7202116) and CETP (show CETP Proteins)(rs1864163) were significant.
genetic association studies in population of adolescents in the United States: Data suggest that an SNP in FTO (rs9939609) is associated with adolescent overweight/obesity and obesogenic appetitive traits (decreased satiety responsiveness and increased food responsiveness) in the population studied.
This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI.
children at risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk. Similarly, children at a higher genetic risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) demonstrated larger NAcc volumes.
Variations within FTO may be predictors of fatty liver disease in HIV-infected patients independently of metabolic factors.
N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A (show GPM6A Proteins)-recognising proteins, including FTO and ALKBH5 (show ALKBH5 Proteins).
Studied weight loss in obese patients with Perilipin 4 (PLIN4 (show PLIN4 Proteins)), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3 (show ADRB3 Proteins)) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4 (show PLIN4 Proteins), FTO, ADRB3 (show ADRB3 Proteins) polymorphisms.
Fat mass and obesity associated (FTO) was the first gene found to be associated with obesity in three independent genome-wide association studies.
It has been shown, that presence of one mutant allele of rs9939609 (gene FTO) and rs4994 (gene ADRB3 (show ADRB3 Proteins)) leads to statistically significant association with obesity.
Food advertisement exposure was associated with greater caloric consumption of a recently advertised food, and this effect was modified by an FTO genotype. Future research is needed to understand the neurological mechanism underlying these associations.
FTO demethylase (show MBD2 Proteins) activity is essential for normal bone development and mineralization, a previously unreported FTO function.
FTO is critically involved in insulin (show INS Proteins) defects-related Alzheimer's disease.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (show HNRNPK Proteins) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (show HNRNPK Proteins) in FTO-associated transformations.
Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.
The involvement of mTOR (show FRAP1 Proteins)-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Proteins) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso