Fat Mass and Obesity-Associated Proteins (FTO)

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (149) and FTO Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
$225.00
Details
Escherichia coli (E. coli) Mouse His tag   10 μg Log in to see 2 to 3 Days
$225.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,424.67
Details

FTO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Fat Mass and Obesity-Associated (FTO) Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. The polymorphism of FTO gene rs17817449 and GNB3 (show GNB3 Proteins) gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R (show MC4R Proteins) Asn274Ser change could not be detected.

  2. A lack of association between FTO polymorphismsand GDM risk.

  3. Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage.

  4. FTO variant is not associated with osteoarthritis in the Chinese Han population.

  5. This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

  6. FTO gene polymorphisms are associated with variability of HDL (show HSD11B1 Proteins)-cholesterol concentrations which may lead to increased CVD risk in patients with acromegaly who are risk-allele carriers.

  7. We observed no evidence for associations of rs1421085 in FTO with FatOx and RQ. This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.

  8. This study reports interactions between the FTO variant and each of: frequency of alcohol consumption; deviations from mean sleep duration; overall diet, including added salt; and physical activity.

  9. FTO rs9939609 Polymorphism is associated with Obesity.

  10. Study showed that a haplotype in the first intron of the FTO gene had a strong association with obesity indices among Iranian adolescent males. None of the students with GGC (show GGCT Proteins) genotypes were underweight, while most of the students with AAT (show SERPINA1A Proteins) had high body mass.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.

  2. FTO demethylase (show MBD2 Proteins) activity is essential for normal bone development and mineralization, a previously unreported FTO function.

  3. FTO is critically involved in insulin (show INS Proteins) defects-related Alzheimer's disease.

  4. This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (show HNRNPK Proteins) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (show HNRNPK Proteins) in FTO-associated transformations.

  5. Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.

  6. The involvement of mTOR (show FRAP1 Proteins)-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.

  7. In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.

  8. propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases

  9. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes.

  10. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.

  2. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  3. In pig, the FTO gene influences back fat depth in the commercial populations.

  4. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  5. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  6. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Proteins) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Protein Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • FTO, alpha-ketoglutarate dependent dioxygenase (FTO)
  • fat mass and obesity associated (Fto)
  • FTO, alpha-ketoglutarate dependent dioxygenase (Fto)
  • fat mass and obesity associated L homeolog (fto.L)
  • AW743446 protein
  • mKIAA1752 protein
  • RGD1305121 protein

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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