Fat Mass and Obesity-Associated Proteins (FTO)

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (144) and FTO Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag   10 μg Log in to see 2 to 3 Days
$225.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
$225.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,424.67
Details

FTO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Fat Mass and Obesity-Associated (FTO) Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Bi-directional relationship between BMI and affective symptoms across the life span, modified by the FTO rs9939609 polymorphism.

  2. We showed that MC4R rs17782313 and FTO rs9939609 were positively associated with zBMI, with weak and very weak effects, respectively, suggesting a very scarce contribution to childhood obesity.

  3. the minor allele A of the rs9939609 has a significant association with increasing BMI values in the Emirati population

  4. There is an association of FTO rs9939609 A/A genotype and impaired fasting glucose and insulin resistance. Homozygous A genotype diabetic patients may be more vulnerable to blood glucose fluctuation.

  5. Our results suggested that genetic variants in the FTO gene were strongly associated with BMI in Chinese women

  6. rs8050136 A/C and rs1588413 C/T associated with polycystic ovary syndrome susceptibility

  7. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions.

  8. Nineteen single nucleotide polymorphisms in the FTO gene were tested. Allelic analysis showed that allele T of SNP rs1121980 was a risk allele. Our study suggests that rs1121980 can become a biomarker for the screening and prognosis of Intervertebral Disc Degeneration

  9. FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents.

  10. FTO polymorphisms appear to be universally associated with the risk of obesity, and further investigation into this genetic locus may provide clues for potential therapeutic targets

  11. The polymorphism of FTO gene rs17817449 and GNB3 gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R Asn274Ser change could not be detected.

  12. A lack of association between FTO polymorphismsand GDM risk.

  13. Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage.

  14. FTO variant is not associated with osteoarthritis in the Chinese Han population.

  15. This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

  16. FTO gene polymorphisms are associated with variability of HDL-cholesterol concentrations which may lead to increased CVD risk in patients with acromegaly who are risk-allele carriers.

  17. We observed no evidence for associations of rs1421085 in FTO with FatOx and RQ. This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.

  18. This study reports interactions between the FTO variant and each of: frequency of alcohol consumption; deviations from mean sleep duration; overall diet, including added salt; and physical activity.

  19. FTO rs9939609 Polymorphism is associated with Obesity.

  20. Study showed that a haplotype in the first intron of the FTO gene had a strong association with obesity indices among Iranian adolescent males. None of the students with GGC genotypes were underweight, while most of the students with AAT had high body mass.

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.

  2. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  3. In pig, the FTO gene influences back fat depth in the commercial populations.

  4. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  5. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  6. transcriptional levels in a range of different tissues under different physiological conditions, and physical mapping of gene

  7. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

  8. Twelve variants including ten SNPs and two indels were detected, and then five SNPs within different genomic regions were genotyped in the ISU Berkshire x Yorkshire pig resource family.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Protein Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • FTO, alpha-ketoglutarate dependent dioxygenase (FTO)
  • fat mass and obesity associated (Fto)
  • FTO, alpha-ketoglutarate dependent dioxygenase (Fto)
  • fat mass and obesity associated L homeolog (fto.L)
  • AW743446 protein
  • mKIAA1752 protein
  • RGD1305121 protein

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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