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The protein encoded by FPB is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Additionally we are shipping Fibrinopeptide B Kits (31) and many more products for this protein.
Showing 6 out of 7 products:
Human Polyclonal FPB Primary Antibody for IHC, IHC (p) - ABIN4311673
Lindén, Segersten, Runeson, Wester, Busch, Pettersson, Lind, Malmström: Tumour expression of bladder cancer-associated urinary proteins. in BJU international 2013
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Human Polyclonal FPB Primary Antibody for IHC, IHC (p) - ABIN4311672
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
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All the exons and exon-intron boundaries of fibrinogen genes (FGA (show FGA Antibodies), FGB (show FGB Antibodies) and FGG (show FGG Antibodies)) were analysed by direct DNA sequencing
High fibrinogen expression is associated with esophageal carcinoma.
Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 (show IL6 Antibodies) and CRP (show CRP Antibodies) were significantly higher in the patients with the CC and CT genotypes.
Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described.
Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.
FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion.
Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.
FGB (show FGB Antibodies) mutations leading to congenital hypofibrinogenaemia
Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors.
There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1 (show IGFBPI Antibodies), CCL20 (show CCL20 Antibodies), CXCL6 and FGB (show FGB Antibodies) were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase (show TXK Antibodies) inhibitors
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
fibrinogen, B beta polypeptide