Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. Additionally we are shipping FOXC2 Kits (28) and FOXC2 Proteins (7) and many more products for this protein.
Showing 10 out of 113 products:
Human Polyclonal FOXC2 Primary Antibody for ELISA, ICC - ABIN249942
Zarbalis, Siegenthaler, Choe, May, Peterson, Pleasure: Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 4 Pubmed References
Human Monoclonal FOXC2 Primary Antibody for IF, IHC (p) - ABIN560913
Nishida, Mimori, Yokobori, Sudo, Tanaka, Shibata, Ishii, Doki, Mori: FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma. in Annals of surgical oncology 2011
Show all 3 Pubmed References
Cow (Bovine) Polyclonal FOXC2 Primary Antibody for WB - ABIN610743
Henis-Korenblit, Strumpf, Goldstaub, Kimchi: A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. in Molecular and cellular biology 2000
Show all 2 Pubmed References
Human Monoclonal FOXC2 Primary Antibody for ELISA, WB - ABIN1724771
Jiang, Pang, Wang, Shen, Chen, Xi: Prognostic role of Twist, Slug, and Foxc2 expression in stage I non-small-cell lung cancer after curative resection. in Clinical lung cancer 2012
Show all 2 Pubmed References
Human Monoclonal FOXC2 Primary Antibody for ELISA, WB - ABIN1724772
Watanabe, Kobunai, Yamamoto, Matsuda, Ishihara, Nozawa, Iinuma, Kanazawa, Tanaka, Konishi, Ikeuchi, Eshima, Muto, Nagawa: Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer. in International surgery 2012
Show all 2 Pubmed References
Foxc2 influences alveolar epithelial cell differentiation during lung development
Study shows that alpha melanocyte stimulating hormone (show POMC Antibodies) and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (show CEBPB Antibodies) negative transcription in mice adipose tissue.
FOXC1 (show FOXC1 Antibodies) and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
Compound, NC-specific Foxc1 (show FOXC1 Antibodies); Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (show PITX2 Antibodies), and its downstream effector Dkk2 (show DKK2 Antibodies), which antagonizes canonical Wnt (show WNT2 Antibodies) signaling.
Foxc1 (show FOXC1 Antibodies) and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. Foxc2 plays a more critical role than Foxc1 (show FOXC1 Antibodies).
Foxc1 (show FOXC1 Antibodies) and Foxc2 have a role in kidney and axial skeleton development.
Our results are consistent with previous reports of Foxc2 expression during early embryogenesis and the Foxc2(CreERT2) mouse provides a tool to investigate spatiotemporal roles of Foxc2 and contributions of Foxc2(+) expressing cells during mouse embryogenesis.
Conditional knockout of Foxc2 gene in kidney has been generated using conditional alleles of single-exon gene by double-selection system.
Data show that segregation of Foxc2 and NFATc1 (show NFATC1 Antibodies) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (show GJA4 Antibodies), Cx43 (show GJA1 Antibodies), and Cx47 (show GJC2 Antibodies).
deletion of Foxc1 (show FOXC1 Antibodies) and Foxc2 specifically in Pax3 (show PAX3 Antibodies)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb
REVIEW: current understanding of FOXC2 and provide potential mechanistic explanations of the relationship between FOXC2 and cancer, as well as discuss the prospect for future research in the promising prognostic value of FOXC2 in cancer
The finding of rare LAMA5 (show LAMA5 Antibodies) variants together with FOXC2 mutations in lymphedema-distichiasis syndrome suggests that these mutations may be co-responsible for these disorders and most likely interfere with the function of lymphatics.
In FOXC2 knockdown cell lines, CXCR4 (show CXCR4 Antibodies), a downstream target of FOXC2, can restore osteosarcoma cell invasiveness and metastasis to the lung
Knockdown of FOXC2 inhibited HCC (show FAM126A Antibodies) cell growth, migration, and invasion in vitro, as well as tumor growth.
Studied interactions between protein kinase C alpha (PKCalpha (show PKCa Antibodies)), FOXC2, and p120-catenin (CTNND1 (show CTNND1 Antibodies)) in breast cancer, cell migration/ invasion; found PKCalpha (show PKCa Antibodies) acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin (show CTNND1 Antibodies), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer.
FOXC2 and CLIP4 activity correlates to the presence of =7-cm clear cell renal cell carcinomas (ccRCCs) with synchronous metastasis and may be potential molecular predictors of synchronous metastasis of =7-cm ccRCCs.
either a complete loss or a significant gain of FOXC2 function can cause a perturbation of lymphatic vessel formation leading to lymphedema.
Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
respectively. Foxc2 is expressed in the developing kidney and therefore congenital renal anomalies may well be associated, potentially as a low penetrance feature. We propose that all individuals diagnosed with Lymphedema distichiasis syndrome should have a baseline renal ultrasound scan at diagnosis
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 (show FOXC1 Antibodies) but also FOXC2 expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 (show FOXC1 Antibodies) in aortic valve anomalies.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in the development of mesenchymal tissues.
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
, forkhead box C2
, forkhead box protein C2
, forkhead box protein C2-like
, brain factor 3
, forkhead homolog 14
, forkhead-related protein FKHL14
, mesenchyme fork head protein 1
, transcription factor FKH-14
, forkhead box C2 (MFH-1 mesenchyme forkhead 1)
, winged helix transcriptional factor MFH-1
, MFH-1,mesenchyme forkhead 1
, forkhead, Drosophila, homolog-like 14