Glutathione S-Transferase alpha 4 Proteins (GSTA4)

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Additionally we are shipping Glutathione S-Transferase alpha 4 Antibodies (89) and Glutathione S-Transferase alpha 4 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GSTA4 2941 O15217
GSTA4 300850 P14942
GSTA4 14860 P24472
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Top Glutathione S-Transferase alpha 4 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$325.00
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$340.00
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$576.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,553.83
Details

GSTA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus) ,
,
Mouse (Murine)

More Proteins for Glutathione S-Transferase alpha 4 (GSTA4) Interaction Partners

Human Glutathione S-Transferase alpha 4 (GSTA4) interaction partners

  1. These findings demonstrate GSTA4 activation during 4-HNE-induced neoplastic transformation in colorectal carcinogenesis. GSTA4 is a potential surrogate biomarker for CRC screening and should provide novel approaches for chemoprevention.

  2. Decreased gene expression of GSTA4 is associated with drug resistance in cervical cancer.

  3. Data indicate that steroidogenic factor 1 (SF-1) and glutathione S-transferase A (GSTA) family genes (hGSTA1-hGSTA4) are involved in steroidogenesis.

  4. drug resistance in three strains of tumor cells is associated with significant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant erythroleukemia and mammary adenocarcinoma cells.

  5. GSTA4 down-regulation and the concomitant increase in 4-hydroxynonenal adducts in muscle are indicative of susceptibility to infection in individuals with severe thermal injuries.

  6. Data show that mandatory overexpression of hGSTA4 by transient transfection in KYSE30 cells and attenuation of HNE-induced EGFR phosphorylation.

  7. analysis of four novel mutations that change the function of leukotriene C(4) synthase and are associated with increased risk of venous thromboembolism and ischemic stroke

  8. Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.

  9. Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes.

  10. GSTA4-4 exploits the hydroxyl group of either 4R- or 4S-hydroxynonenal (HNE), while specifically binding HNE and glutathione (GSH) to maintain high catalytic efficiency linked with stereoselective product formation for both enantiomeric substrates.

  11. ability of the two Alpha class subunit interfaces to adopt a functional heterodimeric structure

  12. expression of hGSTA1/2 and hGSTA4 steady-state mRNAs in second trimester prenatal livers

  13. null mice had a significantly lower survival time than wild-type controls when chronically treated with relatively low doses of paraquat, a finding consistent with a role of glutathione transferase A4-4 in the defense against oxidative stress

  14. We now demonstrate that hGSTA4-transfection also causes a profound change in the expression of genes involved in cell adhesion, cell cycle control, proliferation, cell growth, and apoptosis.

  15. we observed a single nucleotide polymorphism (SNP) G351A leading to the silent mutation Gln117Gln.No significant difference was observed in the distribution of this GSTA4 polymorphism between Parkinson disease individuals and healthy controls

  16. The effect of over-expression of GSTA4 mRNA on the sensitivity of HepG2 cells to 4-hydroxynonenal injury is reported.

  17. These results demonstrate that oxidative stress mediated disruption of tight junctions in endothelial cells may be attenuated by hGSTA4-4 expression.

  18. GSTA4-4 may play an important defensive role against atherogenesis through detoxification of 4-HNE and upregulation of inducible nitric oxide synthase

  19. genetic polymorphisms in GSTA4 had modification effects on smoking-related lung cancer risk, particularly among patients with squamous cell carcinoma and small-cell-lung-cancer.

  20. 4-HNE is involved in p53-mediated signaling in in vitro cell cultures as well as in vivo that can be regulated by glutathione transferase

Mouse (Murine) Glutathione S-Transferase alpha 4 (GSTA4) interaction partners

  1. Data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins.

  2. although loss of GSTA4-4 led to enhanced susceptibility of cardiac mitochondria to radiation-induced loss of morphology, cardiac function was preserved in Gsta4-null mice

  3. These results indicate that 4-HNE significantly contributes to the mechanisms of tubule injury and fibrosis and that these effects can be inhibited by the enhanced expression of GSTA4-4.

  4. In the absence of GSTA4-4 to modulate both physiological and pathological 4-hydroxynonenal (HNE) levels, the adaptive NRF-E2-related (Nrf)2 factor pathway may be primed to contribute to a preconditioned cardiac phenotype in the Gsta4-null mouse.

  5. The naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI. Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI.

  6. 2-APB treatment restrained nasal lavage fluid LTC4, ECP, ovalbumin-specific IgE, and IL-4 and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones.

  7. Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.

  8. Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes.

  9. mGsta4-null mice, in which 4-HNE detoxification is impaired, have an extended life span.

  10. in regenerating hepatocytes, several GST isoforms are induced and that cytokines TNFalpha and IL-6 and survival factor EGF positively regulate mGSTA4 via survival signaling pathways.

  11. mitochondrial Gsta4 is induced under oxidative stress

  12. demonstrated for the first time that protein kinase A and protein kinase C modulate the cytoplasmic and mitochondrial pools GATA4-4

  13. The Gsta4 gene was represented by two EST clones with similar levels of downregulation.

  14. mGSTA4 is strongly increased during oxidative stress via JNK activation.

  15. Excessive malonyl-CoA synthesized by the more abundant and/or allosterically activated ACC in mGsta4 null mice leads to fat accumulation by the well-known mechanisms of promoting fatty acid synthesis and inhibiting fatty acid beta-oxidation.

  16. 4-HNE is involved in p53-mediated signaling in in vitro cell cultures as well as in vivo that can be regulated by glutathione transferase

  17. Compensatory induced GSTA4 plays a protective role against oxidative stress in young SOD1 KO mouse kidneys.

Glutathione S-Transferase alpha 4 (GSTA4) Protein Profile

Protein Summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.

Gene names and symbols associated with GSTA4

  • glutathione S-transferase alpha 4 (GSTA4)
  • glutathione S-transferase alpha 4 (Gsta4)
  • glutathione S-transferase alpha 4-like (GSTA4L)
  • glutathione S-transferase alpha 4 (gsta4)
  • glutathione S-transferase alpha 4 S homeolog (gsta4.S)
  • glutathione S-transferase 3 (GSTA4)
  • glutathione S-transferase, alpha 4 (Gsta4)
  • glutathione S-transferase A4 (LOC100341622)
  • glutathione S-transferase A4 (GSTA4)
  • GST5.7 protein
  • gsta4-4 protein
  • gta4 protein
  • mGsta4 protein
  • tGSTA4 protein

Protein level used designations for GSTA4

GST class-alpha member 4 , S-(hydroxyalkyl)glutathione lyase A4 , glutathione S-alkyltransferase A4 , glutathione S-aralkyltransferase A4 , glutathione S-aryltransferase A4 , glutathione S-transferase A4 , glutathione S-transferase A4-4 , glutathione transferase A4-4 , GST 8-8 , GST A4-4 , GST K , GST Yk , glutathione S-transferase Yk , glutathione S-transferase alpha-4 , glutathione transferase , glutathione S-transferase A3 , glutathione S-transferase class-alpha , glutathione S-transferase alpha class A4 , GSTA4-4 , glutathione S-transferase 5.7 , glutathione S-transferase alpha 4

GENE ID SPECIES
2941 Homo sapiens
300850 Rattus norvegicus
462771 Pan troglodytes
474939 Canis lupus familiaris
533917 Bos taurus
395612 Gallus gallus
549430 Xenopus (Silurana) tropicalis
734548 Xenopus laevis
100379163 Meleagris gallopavo
14860 Mus musculus
100152951 Sus scrofa
100341622 Oryctolagus cuniculus
100056597 Equus caballus
100732190 Cavia porcellus
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