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GORASP2 encodes a member of the Golgi reassembly stacking protein family. Additionally we are shipping Golgi Reassembly Stacking Protein 2, 55kDa Antibodies (98) and and many more products for this protein.
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Results demonstrate a critical role for GRASP55 and GRASP65 in maintaining the stacked structure of the Golgi, which is required for accurate posttranslational modifications in the Golgi. Additionally, the GRASP knockout cell lines developed in this study will be useful tools for studying the role of GRASP proteins in other important cellular processes.
binding site at the cleft between the PDZ1 and PDZ2 domains of GRASP65 is dominated by hydrophobic interactions with GM130 that are not observed in the GRASP55-Golgin45 complex
GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation.
Cisternal-specific functions of GRASP65 and GRASP55 in continuity, compartmentalization, and function of the Golgi ribbon.
propose that GRASP55/65 are negative regulators of exocytic transport and that this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network
GRASP55 may function as an adaptor protein coupling MT1-MMP with furin, thus leading to the activation of the zymogen.
These results demonstrate that GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism.
Data demonstrate that both GRASP55 and 65 are needed for the efficient transport to and through the Golgi complex, thus highlighting a novel role for the GRASPs in membrane trafficking.
GRASP65 is an important structural component required for maintenance of Golgi apparatus integrity
MEK1/ERK regulation of GRASP55-mediated Golgi linking is a control point in cell cycle progression
GRASP55 forms an effector complex for the small GTPase rab2, together with a conserved coiled-coil protein golgin-45 (JEM-1).
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
golgi reassembly stacking protein 2, 55kDa
, Golgi reassembly-stacking protein 2
, golgi reassembly stacking protein 2
, golgi reassembly-stacking protein of 55 kDa
, golgi phosphoprotein 6