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GORASP2 encodes a member of the Golgi reassembly stacking protein family.
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Gorasp2-/- mice suffered from spermatogenesis defects. Golgi morphology of spermatocytes was disturbed in Gorasp2-/- mice. GRASP55 interacted via PDZ-mediated interactions with JAMs.
GRASP55 responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b (show IL1B Proteins) and IL-18 (show IL18 Proteins)
Results demonstrate a critical role for GRASP55 and GRASP65 (show GORASP1 Proteins) in maintaining the stacked structure of the Golgi, which is required for accurate posttranslational modifications in the Golgi. Additionally, the GRASP knockout cell lines developed in this study will be useful tools for studying the role of GRASP proteins in other important cellular processes.
binding site at the cleft between the PDZ1 and PDZ2 domains of GRASP65 (show GORASP1 Proteins) is dominated by hydrophobic interactions with GM130 (show GOLGA2 Proteins) that are not observed in the GRASP55-Golgin45 (show BLZF1 Proteins) complex
GRASP55 interacts with CD83 (show CD83 Proteins) shortly after induction of dendritic cells maturation.
Cisternal-specific functions of GRASP65 (show GORASP1 Proteins) and GRASP55 in continuity, compartmentalization, and function of the Golgi ribbon.
propose that GRASP55/65 are negative regulators of exocytic transport and that this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network
GRASP55 may function as an adaptor protein coupling MT1-MMP (show MMP14 Proteins) with furin (show FURIN Proteins), thus leading to the activation of the zymogen.
These results demonstrate that GRASP55 and GRASP65 (show GORASP1 Proteins) stack mammalian Golgi cisternae via a common mechanism.
Data demonstrate that both GRASP55 and 65 are needed for the efficient transport to and through the Golgi complex, thus highlighting a novel role for the GRASPs in membrane trafficking.
GRASP65 (show GORASP1 Proteins) is an important structural component required for maintenance of Golgi apparatus integrity
MEK1 (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) regulation of GRASP55-mediated Golgi linking is a control point in cell cycle progression
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
golgi reassembly stacking protein 2, 55kDa
, Golgi reassembly-stacking protein 2
, golgi reassembly stacking protein 2
, golgi reassembly-stacking protein of 55 kDa
, golgi phosphoprotein 6