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The protein encoded by HGFA belongs to peptidase family S1.
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HNF1alpha (show HNF1A Antibodies) might regulate beta-cell mass or function at least partly by modulating Hgfac expression.
HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth.
Based upon ethnicity-stratified single-variant association analysis and trans-ethnic meta-analysis of 6201 participants of the Multi-Ethnic Study of Atherosclerosis, discovered 5 common and low-frequency variants: HGF (show HGF Antibodies) missense polymorphism rs5745687 (p.E299K) and 4 variants (rs16844364, rs4690098, rs114303452, rs3748034) within or in proximity to HGFAC.[Meta-analysis]
the HGF-activator has a role in multiple myeloma cells' catalysis of hepatocyte growth factor (HGF (show HGF Antibodies)) activation
HGF (show HGF Antibodies)/MET signaling and aberrant HGF-activator expression is associated with diffuse large B-cell lymphoma
KLK4 (show KLK4 Antibodies) and KLK5 (show KLK5 Antibodies) activate pro-HGFA.
Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor (show HGF Antibodies)/c-Met system via hypoxia inducible factor-1 (show HIF1A Antibodies) in pancreatic cancer.
the activated form of HGFA is present at high levels in serum and bone marrow of myeloma patients, thus providing a necessary prerequisite for the activation of HGF (show HGF Antibodies).
Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein (show MST1 Antibodies).
HAI-1 (show SPINT1 Antibodies) (serine peptidase inhibitor, Kunitz type 1) specifically traps active form of HGF activator on cellular surface and regulates HGF (show HGF Antibodies) activation in pericellular microenvironment.
The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.
, hepatocyte growth factor activator
, hepatocyte growth factor
, Hepatocyte growth factor activator