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HNRNPK belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein K Kits (33) and Heterogeneous Nuclear Ribonucleoprotein K Proteins (15) and many more products for this protein.
Showing 10 out of 166 products:
Mouse (Murine) Monoclonal HNRNPK Primary Antibody for ChIP, ELISA - ABIN108575
Matunis, Michael, Dreyfuss: Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. in Molecular and cellular biology 1992
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Mouse (Murine) Monoclonal HNRNPK Primary Antibody for ChIP, ELISA - ABIN108576
Blanchette, Fuentes Medel, Gardner: Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system. in Gene expression patterns : GEP 2006
Show all 2 Pubmed References
Human Polyclonal HNRNPK Primary Antibody for IF, WB - ABIN516590
Proepper, Steinestel, Schmeisser, Heinrich, Steinestel, Bockmann, Liebau, Boeckers: Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. in PLoS ONE 2011
Chicken Monoclonal HNRNPK Primary Antibody for IHC (p), WB - ABIN2474083
Bomsztyk, Van Seuningen, Suzuki, Denisenko, Ostrowski: Diverse molecular interactions of the hnRNP K protein. in FEBS letters 1997
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The hnRNPK positively regulates the level of prostate tumor overexpressed 1 (show PTOV1 Antibodies)-antisense 1 which harbors five binding sites for miR (show MLXIP Antibodies)-1207-5p. The knockdown of hnRNPK or PTOV1 (show PTOV1 Antibodies)-AS1 (show PTGDR Antibodies) increased the enrichment of heme oxygenase-1 (show HMOX1 Antibodies) mRNA in miR (show MLXIP Antibodies)-1207-5p-mediated miRNA-induced silencing complex and thus suppressed the expression of heme oxygenase-1 (show HMOX1 Antibodies).
High HNRNPK expression is associated with pancreatic cancer.
Down-regulation of DAB2IP (show DAB2IP Antibodies) correlated negatively with hnRNPK and MMP2 (show MMP2 Antibodies) expressions in CRC (show CALR Antibodies) tissues. In conclusion, our study elucidates a novel mechanism of the DAB2IP (show DAB2IP Antibodies)/hnRNPK/MMP2 (show MMP2 Antibodies) axis in the regulation of CRC (show CALR Antibodies) invasion and metastasis, which may be a potential therapeutic target.
Tumor cells bearing a p53 (show TP53 Antibodies) mutation showed increased damage levels and delayed repair. Knockdown of hnRNPK applied simultaneously with irradiation reduced colony-forming ability and survival of tumor cells. Taken together, our data shows that hnRNPK is a relevant modifier of DNA damage repair and tumor cell survival. We therefore recommend further studies to evaluate the potential of hnRNPK as a drug target for improvement
Data suggest that hnRNPK plays role in heat shock response of cells by regulating HSF1; hnRNPK inhibits HSF1 activity, resulting in reduced expression of HSP27 and HSP70 mRNAs; hnRNPK also down-regulates binding of HSF1 to heat shock response element. (hnRNPK = heterogeneous-nuclear ribonucleoprotein K; HSF1 = heat shock transcription factor 1; HSP = heat-shock protein)
KRAS-mutant colorectal carcinoma shows intrinsic radioresistance along with rapid upregulation of hnRNP K in response to ionizing radiation that can effectively be targeted by MEK (show MAP2K1 Antibodies) inhibition.
Nujiangexathone A, a novel compound from Garcinia nujiangensis, down-regulates hnRNPK levels in cervical tumor cells, inducing cell cycle arrest.
Our study also suggests that loss of function variants in HNRNPK should be considered as a molecular basis for patients with Kabuki-like syndrome
these findings support a critical role for hnRNP K in the regulation of autophagy in drug-resistant leukemia cells, and this RNP (show RNPC3 Antibodies) is therefore a potential target of clinical drug-resistance treatment.
hnRNP K is a multifunctional protein that can regulate both oncogenic and tumor suppressive pathways through a plethora of chromatin-, DNA-, RNA-, and protein-mediated activates, suggesting its aberrant expression may have broad-reaching cellular impacts. (Review)
A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo has been described.
a previously unidentified function of phosphorylation at this phylogenetically conserved site and implicates hnRNPK as an intracellular molecular target of ERK (show MAPK1 Antibodies)-mediated signaling in axon outgrowth.
hnRNP K is essential for successful optic axon regeneration via a novel post-transcriptional regulatory pathway.
A crucial role is reported for hnrpk in axon development in Xenoops laevis.
hnRNPK recruits PCGF3 (show PCGF3 Antibodies)/5-PRC1 (show PRC1 Antibodies) to the Xist RNA B-repeat to establish polycomb (show CBX2 Antibodies)-mediated chromosomal silencing.
the beneficial actions of insulin (show INS Antibodies) in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 (show NFE2L2 Antibodies) and Agt (show AGXT Antibodies) gene transcription and preventing Nrf2 (show NFE2L2 Antibodies) stimulation of Agt (show AGXT Antibodies) expression via hnRNP F (show HNRNPF Antibodies)/K.
the cytoplasmic hnRNPK interacts with GSK3beta (show GSK3b Antibodies) and regulates its function.
Data implicate hnRNPK in the development of hematological disorders and suggest hnRNPK acts as a tumor suppressor.
These findings functionally integrate K17 (show KRT17 Antibodies), hnRNP K, and gene expression along with RSK (show RPS6KA1 Antibodies) and CXCR3 (show CXCR3 Antibodies) signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
Nova haploinsufficient mice had spontaneous epilepsy
HnRNP K-3' UTR (show UTS2R Antibodies) complex inhibits TAK1 (show NR2C2 Antibodies) mRNA translation.
hnRNP-K regulates extracellular matrix, cell motility, and angiogenesis pathways. Involvement of the selected genes (Cck (show CCK Antibodies), Mmp-3 (show MMP3 Antibodies), Ptgs2 (show PTGS2 Antibodies), and Ctgf (show CTGF Antibodies)) and pathways was validated by gene-specific expression analysis
HNRNPK affects production of the essential NEAT1_2 isoform by negatively regulating its 3'-end polyadenylation by arresting CFIm (show CPSF6 Antibodies) complex binding near NEAT1_1's alternative polyadenylation site.
Mitochondrial superoxide production stimulated by adiponectin serves as a trigger to initiate the translocation of hnRNP K, which in turn promotes UCP2 (show UCP2 Antibodies) expressions in liver.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference\; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
dC-stretch binding protein
, transformation upregulated nuclear protein
, dC stretch-binding protein
, hnRNP K
, heterogeneous nuclear ribonucleoprotein K
, heterogeneous nuclear ribonucleoprotein k
, hnRNP-K protein
, heterogenous nuclear ribonucleoprotein K
, heterogeneous nuclear ribonucleoprotein K-like