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The protein encoded by HDAC10 belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones.
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this study demonstrated that HDAC10 localizes and functions in the cytoplasm of lung cancer cells, thereby underscoring its potential role in the diagnosis and treatment of lung cancer
HDAC10 regulates cyclin A2 (show CCNA2 ELISA Kits) expression by deacetylating histones near the let-7 promoter.
study identifies an HDAC10-mediated regulatory mechanism controlling the DNA mismatch repair function of MSH2 (show MSH2 ELISA Kits).
Suggest HDAC10 expression as a prognostic marker for gastric cancer.
this study is describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC (show HDAC3 ELISA Kits) isozyme as a druggable regulator of advanced-stage tumor cell survival.
HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 (show MMP2 ELISA Kits) and 9 genes, which are known to be critical for cancer cell invasion and metastasis
results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC (show HDAC3 ELISA Kits) isozyme as a druggable regulator of advanced-stage tumor cell survival
HDAC10 is involved in transcriptional downregulation of TXNIP (show TXNIP ELISA Kits), leading to altered reactive oxygen species signaling in human gastric cancer cells.
Results not only show that HDAC10 regulates melanogenesis but also demonstrate that the transcriptional activities of Pax3 (show PAX3 ELISA Kits) and KAP1 (show CDKN3 ELISA Kits) are intimately linked to their acetylation status.
another histone deacetylase (show HDAC1 ELISA Kits)
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 10