anti-Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) Antibodies

HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. Additionally we are shipping HCFC1 Proteins (30) and HCFC1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HCFC1 3054 P51610
HCFC1 15161 Q61191
HCFC1 363519  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-HCFC1 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HCFC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Stomach Lanes:   Lane1: HIS-HCFC1 16-363aa (42kD) transformed bacteria lysate Lane2: GFP-HCFC1 363-2002aa (73kD) transformed bacteria lysate elution sample  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Anti-rabbit AlexaFluor 680  Secondary Antibody Dilution:   1:10000  Gene Name:   HCFC1  Submitted by:   Anonymous 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  HCFC1  Sample Type:  Uterus Tumor lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of HCFC1 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of HCFC1 expression in HeLa (A), mouse brain (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HCFC1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Anti-HCFC1 / HCF-1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1101977 concentration 10 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$493.17
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of HEK-293, using HCFC1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276914 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of jurkat cells, using HCFC1 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Cerebrum lysate; Primary Ab: 1µg/ml Rabbit Anti-Human HCFC1 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg 15 to 18 Days
$350.00
Details

Top referenced anti-HCFC1 Antibodies

  1. Human Polyclonal HCFC1 Primary Antibody for IP, PLA - ABIN261124 : Parker, Palchaudhuri, Yin, Wei, Chakravarti: A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function. in Molecular and cellular biology 2012 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal HCFC1 Primary Antibody for IP, WB - ABIN261125 : Yu, Mashtalir, Daou, Hammond-Martel, Ross, Sui, Hart, Rauscher, Drobetsky, Milot, Shi, Affar: The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. in Molecular and cellular biology 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against HCFC1 Interaction Partners

Human Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. The HCF-1PRO repeat possesses an important extended threonine-rich region that is tightly bound by the OGT tetratricopeptide-repeat region. This region confers both glycosylation and proteolytic activities to HCF-1.

  2. Data show that Myc boxes (MbIV) is required for the association of MYC with the abundant transcriptional coregulator host cell factor-1 (HCF-1).

  3. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1

  4. Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)

  5. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function

  6. O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification

  7. These results demonstrate that distinct OGT-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.

  8. our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.

  9. We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation.

  10. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy.

  11. study reports the tetratricopeptide-repeat domain of O-GlcNAc transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site

  12. A missense mutation in a global transcriptional coregulator, HCFC1, was identified as the genetic basis of an X-linked form of combined methylmalonic acidemia and hyperhomocysteinemia.

  13. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.

  14. MLL5 can associate with HCF-1 and then be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation.

  15. A noncoding, regulatory mutation was identified in the binding site of transcription factor YY1 in the HCFC1 gene in patients with nonsyndromic intellectual disability.

  16. Host cell factor C1 recruits O-GlcNAc transferase to O-GlcNAcylate PGC-1alpha, and O-GlcNAcylation facilitates the binding of the deubiquitinase BAP1, thus protecting PGC-1alpha from degradation and promoting gluconeogenesis.

  17. HCF-1(N)-HCF-1(C) association via an integrated Fn3 structure permits an NLS to facilitate formation of a transcriptional regulatory complex

  18. THAP11 was found to associate physically with the transcriptional coregulator HCF-1 (host cell factor 1) and recruit HCF-1 to target promoters

  19. Studies suggest that BAP1 influences cell proliferation at G1/S by co-regulating transcription from HCF-1/E2F-governed promoters.

  20. These results reveal an unexpected role of OGT in HCF-1 proteolytic maturation and an unforeseen nexus between OGT-directed O-GlcNAcylation and proteolytic maturation in HCF-1 cell-cycle regulation.

Mouse (Murine) Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. These studies indicate HCF-1 is critical for glucocorticoid receptor activation of the viral immediate early genes and suggests that glucocorticoid induction of viral reactivation proceeds via an HCF-1- glucocorticoid receptor mechanism in the absence of the viral immediate early activator VP16.

  2. male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation.

  3. Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)

  4. survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele

  5. our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.

  6. These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.

  7. Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.

  8. HCF-1 is an important component of the viral latency-reactivation cycle and it is regulated by association with a component that is distinct from the identified HCF-1 interaction factors

  9. Bap1 helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition

Zebrafish Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC expression

HCFC1 Antigen Profile

Protein Summary

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Gene names and symbols associated with HCFC1

  • host cell factor C1 (HCFC1) antibody
  • host cell factor C1 (Hcfc1) antibody
  • host cell factor C1a (hcfc1a) antibody
  • host cell factor (LOC5571204) antibody
  • host cell factor C1 (CpipJ_CPIJ014908) antibody
  • host cell factor C1 (VP16-accessory protein) (HCFC1) antibody
  • AW060991 antibody
  • CFF antibody
  • fc61g09 antibody
  • HCF antibody
  • HCF-1 antibody
  • HCF1 antibody
  • HCFC1 antibody
  • HFC1 antibody
  • im:7159458 antibody
  • MRX3 antibody
  • RGD1563804 antibody
  • VCAF antibody
  • wu:fc61g09 antibody
  • wu:fj40c12 antibody

Protein level used designations for HCFC1

C1 factor , HCF , VP16 accessory protein , host cell factor 1 , VP16-accessory protein , etID52682.11 , host cell factor C1

GENE ID SPECIES
3054 Homo sapiens
15161 Mus musculus
363519 Rattus norvegicus
564853 Danio rerio
5571204 Aedes aegypti
6048549 Culex quinquefasciatus
100137257 Papio anubis
100328750 Oryctolagus cuniculus
492246 Canis lupus familiaris
512908 Bos taurus
101830931 Mesocricetus auratus
Selected quality suppliers for anti-HCFC1 (HCFC1) Antibodies
Did you look for something else?