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HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal.
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Human Polyclonal HCFC1 Primary Antibody for IP, PLA - ABIN261124
Parker, Palchaudhuri, Yin, Wei, Chakravarti: A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function. in Molecular and cellular biology 2012
Show all 3 Pubmed References
Human Polyclonal HCFC1 Primary Antibody for IP, WB - ABIN261125
Yu, Mashtalir, Daou, Hammond-Martel, Ross, Sui, Hart, Rauscher, Drobetsky, Milot, Shi, Affar: The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. in Molecular and cellular biology 2010
Data show that Myc (show MYC Antibodies) boxes (MbIV) is required for the association of MYC (show MYC Antibodies) with the abundant transcriptional coregulator host cell factor-1 (HCF-1).
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Antibodies)-element, which engages a THAP11 (show THAP11 Antibodies)/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros (show IKZF1 Antibodies) and NFKB1 (show NFKB1 Antibodies)
Beyond its well-known role in adding beta-O-GlcNAc (show OGT Antibodies) to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (show OGT Antibodies) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function
O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2 (show TET2 Antibodies)) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification
These results demonstrate that distinct OGT (show OGT Antibodies)-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.
our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.
We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation.
THAP11 (show THAP11 Antibodies), ZNF143 (show ZNF143 Antibodies), and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F (show E2F1 Antibodies) occupancy.
study reports the tetratricopeptide-repeat domain of O-GlcNAc (show OGT Antibodies) transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase (show GTDC2 Antibodies) active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site
male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation.
Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (show OGT Antibodies) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele
These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.
Ronin (show THAP11 Antibodies)/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
HCF-1 is an important component of the viral latency-reactivation cycle and it is regulated by association with a component that is distinct from the identified HCF-1 interaction factors
Bap1 (show BAP1 Antibodies) helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition
HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC (show MMACHC Antibodies) expression
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
, VP16 accessory protein
, host cell factor 1
, VP16-accessory protein
, host cell factor C1