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Increases intracellular lipid accumulation. Additionally we are shipping HILPDA Antibodies (10) and and many more products for this protein.
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Authors conclude that Hig2 localizes to LDs in adipocytes, promoting adipose tissue lipid deposition and that its selective deficiency in active brown/beige adipose tissue mediates improved glucose tolerance at 23 degrees C.
Thus, macrophage Hilpda is crucial to foam-cell formation and lipid deposition, and to controlled prostaglandin-E2 production. By these means Hilpda promotes lesion formation and progression of atherosclerosis
HILPDA is highly abundant in adipose tissue, where its levels are induced by peroxisome proliferator-activated receptor gamma and beta-adrenergic stimulation. In contrast to the reported inhibition of lipolysis by HILPDA in hepatocytes, those data do not support an important direct role of HILPDA in the regulation of lipolysis in adipocytes in vivo and in vitro.
When fasted, HILPDA KO mice are unable to maintain body temperature and become hypothermic at 22 degrees C.
data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion.
HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas
The expression of HIG2 was regulated by PVT1-miR-150 signaling, we transfected Hep G2 and BEL-7402 cell lines with PVT1 shRNA vectors or the combination of PVT1 shRNA vectors and miR-150 inhibitors.
Authors conclude that HIG2 is overexpressed in GBM and upregulated by hypoxia.
Study showed for the first time that HIG-2 and SOX11 mutually co-regulate each other, and that HIG-2 and SOX11 knock-down promote increased proliferation in a non-synergistic manner in primary mantle cell lymphoma cells.
Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha target in regulating cell survival during hypoxia.
there was no significant relationship between HIG2 expression and age, clinical stage and histology in either cervical cancer or endometrial cancer.
Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein.
may be used as a marker for early detection of ovarian clear cell adenocarcinoma
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity).
hypoxia-inducible gene 2 protein
, hypoxia-inducible lipid droplet-associated protein
, hypoxia inducible gene 2
, hypoxia-inducible protein 2