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The protein encoded by ISCA2 is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. Additionally we are shipping Iron-Sulfur Cluster Assembly 2 Homolog (S. Cerevisiae) Antibodies (24) and many more products for this protein.
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We identified a homoallelic missense founder mutation in ISCA2 leading to mitochondrial depletion and reduced complex I activity as well as decreased ISCA2, ISCA1 (show ISCA1 Proteins) and IBA57 (show IBA57 Proteins) expression in fibroblasts.
The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 (show GLRX5 Proteins) is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 (show ISCA1 Proteins) and ISCA2 by a specific protein-protein recognition mechanism.
ISCA1 (show ISCA1 Proteins), ISCA2, and IBA57 (show IBA57 Proteins) were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis.
Data suggest that miR (show MLXIP Proteins)-210 induced repression of ISCU1/2 may contribute to HIF-1alpha (show HIF1A Proteins)-triggered alterations in neuronal energy metabolism after nickel exposure.
The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene.
HESB-like domain-containing protein 1
, iron-sulfur cluster assembly 2 homolog, mitochondrial
, HESB like domain containing 1
, iron-sulfur cluster assembly 2 homolog