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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
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KIR2DS1 expression by decidual natural killer cells increases their ability to control placental HCMV infection
A negative association between the KIR2DS1 polymorphism and susceptibility to type 1 diabetes mellitus was found.
the surface organization of paired killer Ig-like receptors (KIR (show GEM Proteins)), KIR2DL1 (show KIR2DL1 Proteins) and KIR2DS1, on human primary natural killer cells and cell lines, was examined.
KIR2DS1 gene polymorphism is associated with HIV-1 infection.
The absence of KIR-2DS1 in the mother and the presence of HLA-C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA-C2 may contribute to the risk of type 1 diabetes among Han Chinese children
KIR2DS1-C2C2 is less frequent in type 1 diabetes in Saudi children
Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 is Associated with an Increased HLA-C2 Allelic Frequency
functional interactions between KIR (show GEM Proteins) and HLA modify risks of BCC and SCC (show CYP11A1 Proteins) and that KIR (show GEM Proteins) encoded by the B genes provides selective pressure for altered p53 (show TP53 Proteins) in BCC tumors.
The activating KIR (show GEM Proteins) gene KIR2DS1 has an important predictive potential for early onset of type 1 autoimmune hepatitis.
Absence of HLA-C2 for donor KIR2DL1 (show KIR2DL1 Proteins) was associated with higher grade II to IV (HR, 1.4; P = .002) and III to IV acute GVHD (HR, 1.5; P = .01) compared with HLA-C2(+) patients.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
CD158 antigen-like family member H
, MHC class I NK cell receptor Eb6 ActI
, killer cell immunoglobulin-like receptor 2DS1
, killer cell immunoglobulin-like receptor KIRDS1
, killer-cell immunoglobulin-like receptor