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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
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Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).
KIR2DS2/HLA-C1 may correlate with Hashimoto thyroiditis in a Chinese population.
Loss of KIR2DS2 gene is associated with breast cancer.
association between KIR2DS2 and the response to methotrexate (MTX (show MTX1 Proteins)), moreover, the combination KIR2DL2 (show KIR2DL2 Proteins)+/KIR2DS2+ was more frequent in responders to MTX (show MTX1 Proteins) (p = 0.043).
this study shows that the presence of KIR2DS2 was associated with a worsening of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies
this study was to look for immunogenetic determinants in the pathogenesis of FMF (show MEFV Proteins) and find out if KIR (show GEM Proteins) are related to susceptibility. An activator KIR (show GEM Proteins) gene, KIR2DS2, was significantly more frequent in FMF (show MEFV Proteins) patients (p=0.036).
a significant increase in the frequency of KIR2DL2 (show KIR2DL2 Proteins) (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma (show ARHGEF16 Proteins) compared with the healthy control group, was found.
Single Nucleotide Polymorphism in KIR2DS2 gene is associated with Asthma and Atopic Dermatitis.
KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population.
CD4 (show CD4 Proteins)(+) CD28 (show CD28 Proteins)(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 (show KIR2DL3 Proteins) and increased DAP12 (show TYROBP Proteins) expression in HD-ESRD compared with NDD (show NDD Proteins)-CKD patients.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
, CD158 antigen-like family member J
, MHC class I NK cell receptor
, NK receptor 183 ActI
, killer cell immunoglobulin-like receptor 2DS2
, killer-cell Ig-like receptor
, killer-cell immunoglobulin-like receptor two domains short tail 2 protein
, natural killer associated transcript 5
, natural killer cell inhibitory receptor
, natural killer-associated transcript 5
, p58 KIR
, p58 NK receptor CL-49
, p58 killer cell inhibitory receptor KIR-K7a
, p58 natural killer cell receptor clone CL-49