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Members of the LY6 protein family (see SLURP1\; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010].. Additionally we are shipping LYPD6 Kits (11) and LYPD6 Antibodies (7) and many more products for this protein.
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Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling.
Results indicate the key role in the interaction of LY6/PLAUR domain containing 6 (LYPD6) with LDL receptor related protein 6 (LRP6).
the Lynx protein Lypd6 binds to nAChRs in human brain extracts, and that recombinant Lypd6 decreases nicotine-induced ERK phosphorylation
The cloning and characterization of a novel human LU domain containing gene, LYPD6, isolated from human testis cDNA library, is reported.
Study employ the marble burying (MB) and elevated zero maze (EZM) tests in Lypd6 knock-out (KO) and wild-type (WT) mice and find that loss of Lypd6 leads to decreased digging behaviour in the MB test and increased time spent in the open area in the EZM test; demonstrate that acute nicotine administration reduces digging in the MB test in both KO and WT mice and further accentuates the inherent genotype difference.
Lypd6 seems to constitute a novel modulator of nAChRs that affects receptor function by selectively increasing Ca2+-influx through ion channels
Members of the LY6 protein family (see SLURP1\; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010
ly6/PLAUR domain-containing protein 6
, LY6/PLAUR domain containing 6
, ly6/PLAUR domain-containing protein 6-like