Lamin B Receptor Proteins (LBR)

The protein encoded by LBR belongs to the ERG4/ERG24 family. Additionally we are shipping Lamin B Receptor Antibodies (83) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LBR 3930 Q14739
LBR 98386 Q3U9G9
Rat LBR LBR 89789 O08984
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Top Lamin B Receptor Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days

LBR Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

More Proteins for Lamin B Receptor (LBR) Interaction Partners

Fruit Fly (Drosophila melanogaster) Lamin B Receptor (LBR) interaction partners

  1. dLBR is not a limiting component of the nuclear architecture in Drosophila cells during the first 2 days of development

Zebrafish Lamin B Receptor (LBR) interaction partners

  1. Data indicate that the LBR of zebrafish and mammals are both required for correct development of embryos.

Xenopus laevis Lamin B Receptor (LBR) interaction partners

  1. LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta (show KPNB1 Proteins) in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis

Human Lamin B Receptor (LBR) interaction partners

  1. The authors demonstrate that human LBR is essential for cholesterol synthesis.

  2. These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network.

  3. The primary response of cells to various stresses leading to senescence consists of the down-regulation of LBR and LB1 (show CKAP2 Proteins) to attain reversal of the chromatin architecture.

  4. We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells.

  5. Data indicate that proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)) phosphorylates distinct sites than SRPK1 (show SRPK1 Proteins) protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR).

  6. Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 (show KPNA1 Proteins) vs. NPI3 - 0.00 vs. 0.00; p = 0.0551).

  7. Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype.

  8. Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation.

  9. LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly

  10. The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C (show LMNA Proteins) during in vitro granulopoiesis induced with retinoic acid.

Mouse (Murine) Lamin B Receptor (LBR) interaction partners

  1. The diffusional mobility of full-length LBR shows significant regional variation along the nuclear envelope, consistent with the existence of discrete LBR microdomains and the occurrence of multiple, asymmetrically-spaced anastomoses along the nuclear envelope-endoplasmic reticulum interface. Native LBR may be "configured" by long-range interactions between adjacent transmembrane domains and parts of the NH2 region.

  2. These results show a moderate skin differentiation phenotype, which indicates that upregulation of LBR is not the sole contributor to the Hutchinson-Gilford progeria syndrome phenotype.

  3. The N-terminal portion of LBR is probably responsible for the binding to HP1b (show CBX1 Proteins).

  4. Study identified LBR- and lamin-A/C (show LMNA Proteins)-dependent mechanisms tethering heterochromatin to the nuclear envelope. The two tethers are sequentially used during cellular differentiation and development: first the LBR- and then the lamin-A/C (show LMNA Proteins)-dependent tether.

  5. LBR deficiency affects not only nuclear architecture but also proliferation, cell viability, and gene expression of hematopoietic cells

  6. sterol Delta(14) reductase domain of LBR plays a critical role in cholesterol biosynthesis and that this process is essential to both myeloid cell growth and functional maturation.

  7. Lbr, under transcriptional regulation of C/EBPepsilon (show CEBPE Proteins), is necessary for morphological but not necessarily functional granulocyte maturation.

  8. lamin B receptor, although residing in nuclear membranes, may contribute to cholesterol biosynthesis in Tm7sf2 (show TM7SF2 Proteins)((-/-)) mice

Lamin B Receptor (LBR) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Gene names and symbols associated with Lamin B Receptor Proteins (LBR)

  • lamin B receptor (LBR)
  • Lamin B receptor (LBR)
  • lamin B receptor (lbr)
  • lamin B receptor S homeolog (lbr.S)
  • lamin B receptor (Lbr)
  • AI505894 protein
  • CG17952 protein
  • DHCR14B protein
  • dLBR protein
  • Dmel\\CG17952 protein
  • ic protein
  • LBR protein
  • lbr-A protein
  • LMN2R protein
  • Nbp60 protein
  • p58 gene protein
  • PHA protein
  • sb:cb406 protein
  • TDRD18 protein
  • wu:fb75h08 protein
  • wu:fc47b04 protein
  • wu:fd36b07 protein
  • Xp58 protein
  • zgc:86649 protein

Protein level used designations for Lamin B Receptor Proteins (LBR)

CG17952-PA , CG17952-PB , CG17952-PC , LBR-PA , LBR-PB , LBR-PC , lamin B receptor , lamin-B receptor , lamin-B receptor-like , integral nuclear envelope inner membrane protein , tudor domain containing 18 , ichthyosis , Lamin-B receptor

100056997 Equus caballus
37482 Drosophila melanogaster
368360 Danio rerio
378609 Xenopus laevis
457776 Pan troglodytes
490391 Canis lupus familiaris
700801 Macaca mulatta
100145693 Xenopus (Silurana) tropicalis
100415074 Callithrix jacchus
100470463 Ailuropoda melanoleuca
100594061 Nomascus leucogenys
3930 Homo sapiens
98386 Mus musculus
89789 Rattus norvegicus
509348 Bos taurus
396285 Gallus gallus
100174610 Pongo abelii
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