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G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Antibodies (89) and LGR4 Kits (17) and many more products for this protein.
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the host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells.
High LGR4 expression is associated with osteoarthritis.
Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation.
LGR4 is another receptor for RANKL (show TNFSF11 Proteins). LGR4 competes with RANK to bind RANKL (show TNFSF11 Proteins) and suppresses canonical RANK signaling during osteoclast differentiation.
The LGR4 A750T variant is correlated with central obesity-related characteristics in young subjects.
Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1 (show MAP2K1 Proteins)/ERK1/2 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.
miR (show MLXIP Proteins)-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration and adhesion partly by suppressing LGR4 expression.
Lgr4 activates Jmjd2a/AR signaling pathway to promote interaction AR with PSA promoter, causing reduction of prostate cancer apoptosis and cell cycle arrest.
A mechanistic understanding of RANKL (show TNFSF11 Proteins)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Proteins) signaling in osteoporosis and other diseases
miR (show MLXIP Proteins)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways in the LNCaP-IL-6 (show IL6 Proteins)+ cells.
LGR4 is another receptor for RANKL (show TNFSF11 Proteins). LGR4 competes with RANK to bind RANKL (show TNFSF11 Proteins) and suppresses canonical RANK signaling during osteoclast differentiation. Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast number, surface area, and size) and increased bone erosion.
RSPO (show RSPO1 Proteins)-LGR4/5-ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
These date indicate that hydrogen peroxide suppresses Lgr4 expression in osteoblastic cells.
Lgr4 gene is regulated by BMP and is required for BMP effects on osteoblastic differentiation.
Rspo1 (show RSPO1 Proteins) and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling for bone formation.
Study suggests that miR (show MLXIP Proteins)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008
G protein-coupled receptor 48
, leucine-rich repeat-containing G-protein coupled receptor 4
, G protein-coupled receptor GPR48
, G-protein coupled receptor 48