anti-Lin-28 Homolog B (C. Elegans) (LIN28B) Antibodies

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
LIN28B 689054  
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Top anti-LIN28B Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of anti-LIN28B Pab (ABIN388297) in K562 cell line lysates (35 µg/lane). LIN28B(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28B antibody (Center) (ABIN388297), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of LIN28B Antibody (N-term) (ABIN388295) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human Testis tissue reacted with LIN28B Antibody (N-term)(ABIN388295), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of LIN28B Antibody (C-term) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Flow cytometric analysis of HL-60 cells using LIN28B Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 0.2 mL Log in to see 11 to 13 Days
$542.85
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Raji cell lysates probed with Rabbit Anti-Lin-28B Polyclonal Antibody, Unconjugated (ABIN1387887) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 90min in 37˚C. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse Un-conjugated IF, IHC, WB   100 μL Log in to see 16 Days
$391.88
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB Western blot analysis of extracts of HEK-293 cells, using LIN28B antibody. 100 μL Log in to see 16 Days
$323.13
Details

LIN28B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LIN28B Antibodies

  1. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388295 : Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LIN28B Primary Antibody for FACS, WB - ABIN388296 : Beachy, Onozawa, Chung, Slape, Bilke, Francis, Pineda, Walker, Meltzer, Aplan: Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. in Blood 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388297 : Mongroo, Noubissi, Cuatrecasas, Kalabis, King, Johnstone, Bowser, Castells, Spiegelman, Rustgi: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. in Cancer research 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. common genetic variations (rs7759938 and rs314280) of LIN28B may contribute to idiopathic central precocious puberty susceptibility in Chinese girls

  2. these findings reveal that lncRNA H19 (show NCKAP1 Antibodies), miRNA let-7 and transcriptional factor LIN28 (show LIN28A Antibodies) form a double-negative feedback loop, which has a critical role in the maintenance of breast cancer stem cells.

  3. Authors show that mature Let-7 miRNAs are regulated during hESC differentiation and have opposite expression profile with LIN28B. Moreover, mature Let-7 miRNAs fine tune the expression levels of LIN28B protein in pluripotent hESCs, whereas silencing of LIN28 (show LIN28A Antibodies) proteins have no effect on mature Let-7 levels.

  4. LIN28A (show LIN28A Antibodies) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  5. The identification of the let-7/Lin28 (show LIN28A Antibodies) axis as an important regulator of HSC (show FUT1 Antibodies) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  6. the LIN28B rs221634 A>T polymorphism was associated with an increased neuroblastoma (show ARHGEF16 Antibodies) risk in Southern Chinese children.

  7. Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 Antibodies) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (show LIN28A Antibodies) expression.

  8. LIN28B orchestrates oncogenic signaling in neuroblastoma (show ARHGEF16 Antibodies).

  9. loss of SIRT6 (show SIRT6 Antibodies) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (show MYC Antibodies) transcription factor to drive its expression

  10. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Study generated transgenic mice that either overexpressed Lin28b in Math1 (show ATOH1 Antibodies)-positive cerebellar granule neuron precursors or in a broad range of Nestin (show NES Antibodies)-positive neural precursors; while overexpression of LIN28B in Nestin (show NES Antibodies)-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  2. this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells

  3. expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.

  4. loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 (show SMAD2 Antibodies) proteins. A reduction in TGF-beta (show TGFB1 Antibodies) signaling leads to reduced Treg numbers.

  5. Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR (show MLXIP Antibodies)-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.

  6. LIN28A (show LIN28A Antibodies) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  7. The identification of the let-7/Lin28 (show LIN28A Antibodies) axis as an important regulator of HSC (show FUT1 Antibodies) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  8. data point toward a complex system of regulation by Lin28a (show LIN28A Antibodies), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  9. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  10. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ Antibodies) plasticity.

LIN28B Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B S homeolog (lin28b.S) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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