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LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Additionally we are shipping Loricrin Kits (7) and Loricrin Proteins (4) and many more products for this protein.
Showing 10 out of 19 products:
Chemical Polyclonal LOR Primary Antibody for ICC, IF - ABIN443470
Shigehara, Okuda, Nemer, Chedraoui, Hayashi, Bitar, Nakai, Abbas, Daou, Abe, Sleiman, Kibbi, Kurban, Shimomura: Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis. in Human molecular genetics 2016
Authors report a multi-generation family with prominent ichthyosis (show LBR Antibodies) and palmoplantar involvement due to a novel mutation in loricrin.
Letter: Knockdown of either filaggrin (show FLG Antibodies) or loricrin increases the productions of interleukin (IL)-1alpha, IL-8 (show IL8 Antibodies), IL-18 (show IL18 Antibodies) and granulocyte macrophage colony-stimulating factor (show CSF2 Antibodies) in stratified human keratinocytes.
Studies on human keratinocytes recognized that loricrin expression was inversely related to the expression of the cyclin-dependent kinase (show CDK1 Antibodies) inhibitor p21 (show CDKN1A Antibodies)
two novel heterozygous frameshift mutations in exon 2 - c.646_647insGCAGCAGGTC, p.Gln216Argfs*123 and c.798_799dupT, p.Gly267Trpfs*69 in loricrin keratoderma patients
Results describe a novel frameshift mutation leading to loricrin keratoderma presenting with colloidion membrane
We found no mutations of Loricrin in two Progressive symmetrical erythrokeratoderma families.
We describe a young man who was a collodion baby and had the typical presentation of Loricrin keratoderma. Direct DNA sequencing identified a heterozygous mutation in the loricrin gene with a single G insertion, 730insG, present in (a) the patient
There were no mutations found in the LOR gene and the true pathogenesis of progressive symmetrical erythrokeratodermia remains unknown.
identified mRNA transcripts from three genes CDSN (show CDSN Antibodies), LOR and KRT9 (show KRT9 Antibodies), showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification
VEGF (show VEGFA Antibodies) release and the subsequent activation of VEGF receptor 2 link loricrin gene mutations to rapid cell proliferation in a cellular model of loricrin keratoderma.
the late cornified envelope 1 proteins are regulated by NRF2 (show NFE2L2 Antibodies) and are compensatory components for loricrin as determined by their localization within the loricrin knockout cell envelope via immunoelectron microscopy
Oct-6 (show POU3F1 Antibodies) and Oct-11 (show POU2F3 Antibodies) contribute to the regulation of loricrin gene transcription via interaction with AP-1 (show JUN Antibodies) factors and Sp1 (show SP1 Antibodies)/Sp3 (show SP3 Antibodies).
In the absence of loricrin, S. aureus nasal colonisation was significantly impaired.
The decreased expression of epidermal growth factor receptor (EGFR (show EGFR Antibodies)), E-cadherin (show CDH1 Antibodies), occludin (show OCLN Antibodies), and SIRT1 (show SIRT1 Antibodies) in the skin of Flg(ft (show FLG Antibodies)) mice, compared with those in C57BL/6J mice, is reported.
These results indicate AASS (show AASS Antibodies) knockdown decreases the lysine requirement of the cell via a reduction of lysine catabolism through the saccharopine pathway.
Mice receiving the high-protein diet had greater AASS (show AASS Antibodies) mRNA compared to mice fed the adequate protein diet.
YY1 (show YY1 Antibodies) contributes to specific loricrin gene expression in differentiated keratinocytes by suppression of its transcription in undifferentiated keratinocytes.
nectin-1 (show PVRL1 Antibodies) plays a key role in the expression of loricrin in the epidermis
Skin biopsies from STAT6 (show STAT6 Antibodies) transgenic mice were deficient in the expression and production of loricrin and involucrin (show IVL Antibodies).
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
, alpha-aminoadipic semialdehyde synthase, mitochondrial
, lysine oxoglutarate reductase
, saccharopine dehydrogenase