Lysyl Oxidase Proteins (LOX)

The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Additionally we are shipping LOX Antibodies (179) and LOX Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LOX 4015 P28300
LOX 16948 P28301
LOX 24914 P16636
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Top LOX Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$672.00
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Yeast Rat His tag Lysyl Oxidase (LOX) (AA 163-411) protein (His tag) expressed in E. coli 1 mg Log in to see 60 to 71 Days
$2,638.17
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$1,152.00
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,638.17
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,638.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,638.17
Details

LOX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced LOX Proteins

  1. Human LOX Protein expressed in HEK-293 Cells - ABIN2712316 : Baker, Bird, Welti, Gourlaouen, Lang, Murray, Reynolds, Cox, Erler: Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis. in Cancer research 2013 (PubMed)
    Show all 5 Pubmed References

  2. Mouse (Murine) LOX Protein expressed in Escherichia coli (E. coli) - ABIN2123209 : Tsukasaki, Hamada, Okamoto, Nagashima, Terashima, Komatsu, Win, Okamura, Nitta, Yasuda, Penninger, Takayanagi: LOX Fails to Substitute for RANKL in Osteoclastogenesis. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 (PubMed)

More Proteins for Lysyl Oxidase (LOX) Interaction Partners

Zebrafish Lysyl Oxidase (LOX) interaction partners

  1. Partial knockdown of lysyl oxidase genes sensitizes the developing embryo to dithiocarbamate exposure.

  2. Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.

Human Lysyl Oxidase (LOX) interaction partners

  1. LOX role in cancer stromal cells activation and promotion of gastric cancer progression

  2. an association of LOX gene polymorphism (G473A) on diabetes and DFU patients

  3. LOX expression was mildly but significantly upregulated in CD34 (show CD34 Proteins)+-derived primary myelofibrosis megakaryocytes and platelets compared with controls. These megakaryocytes showed a greater tendency to adhere and spread to monomeric collagen, and this was inhibited by the LOX-specific inhibitor BAPN (show ANPEP Proteins).

  4. Data suggest that a missense mutation in lysyl oxidase (LOX) is associated with aortic disease.

  5. Our findings suggest that LOX has a role in cancer cell mitosis

  6. Our findings provide new evidence that LOX regulates SNAI2 expression and that SNAI2-mediated TIMP4 (show TIMP4 Proteins) secretion plays a role in cancer progression.

  7. UXT (show UXT Proteins) Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha (show ESR1 Proteins) Activity in Breast Cancer Cells.

  8. LOX is a prognostic factor for poor progression free survival in patients with ER- breast cancer. LOX overexpression was positively correlated with resistance to radiation and drug therapy.

  9. This preliminary study indicated that LOX gene polymorphisms, such as rs2303656, rs3900446, and rs763497, may play crucial roles in intracranial aneurysm formation in the Korean population.

  10. Results show that CTGF (show CTGF Proteins) mediates the GDF8 (show MSTN Proteins)-induced up-regulation of LOX expression and increases in LOX activity in human granulosa cells.

Pig (Porcine) Lysyl Oxidase (LOX) interaction partners

  1. Statins normalize vascular lysyl oxidase (LOX) down-regulation induced by proatherogenic risk factors.

Cow (Bovine) Lysyl Oxidase (LOX) interaction partners

  1. These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.

  2. Lysyl oxidase enhances elastin (show ELN Proteins) synthesis and matrix formation by vascular smooth muscle cells

  3. Lysyl oxidase has a role in oxidizing basic fibroblast growth factor (show FGF2 Proteins) and inactivating its mitogenic potential

  4. In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.

  5. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.

Mouse (Murine) Lysyl Oxidase (LOX) interaction partners

  1. LOX up-regulation is associated with enhanced oxidative stress that promotes p38MAPK (show MAPK14 Proteins) activation, elastin (show ELN Proteins) structural alterations, and vascular stiffness.

  2. These results suggest that LOX has the ability to induce RANKL (show TNFSF11 Proteins) expression on stromal cells; however, it fails to substitute for RANKL (show TNFSF11 Proteins) in osteoclastogenesis.

  3. UXT (show UXT Proteins) Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha (show ESR1 Proteins) Activity in Breast Cancer Cells.

  4. Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 (show FGF2 Proteins) receptor signaling.

  5. LOX targeting reduces peritoneal fibrosis.

  6. Absence of lysyl oxidase (Lox) causes thoracic aortic aneurysms. The aortic mechanical behavior of Lox(-/-) mice is consistent with reduced elastin (show ELN Proteins) and collagen cross-linking but demonstrates vascular location-specific differences. Lox(-/-) aortas show upregulation of matrix remodeling genes and location-specific differential expression of other matrix and smooth muscle cell gene sets.

  7. Findings from this study indicate that preventing LOX overexpression may be protective against high glucose-induced apoptosis in retinal vascular cells associated with diabetic retinopathy.

  8. LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery

  9. Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.

  10. The data suggest a fibromodulin (show FMOD Proteins)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD Proteins) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

LOX Protein Profile

Protein Summary

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Lysyl Oxidase Proteins (LOX)

  • lysyl oxidase (LOX)
  • lysyl oxidase (lox)
  • lysyl oxidase a (loxa)
  • lysyl oxidase L homeolog (lox.L)
  • lysyl oxidase (Lox)
  • AI893619 protein
  • H-rev142 protein
  • lox protein
  • MGC146507 protein
  • Rrg1 protein
  • TSC-160 protein
  • Xlox protein
  • zgc:77447 protein

Protein level used designations for Lysyl Oxidase Proteins (LOX)

lysyl oxidase , protein-lysine 6-oxidase-like , protein-lysine 6-oxidase , ras excision protein , ras recision gene (rrg) , Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)

GENE ID SPECIES
471614 Pan troglodytes
699997 Macaca mulatta
780067 Xenopus (Silurana) tropicalis
100189621 Oncorhynchus mykiss
100457685 Pongo abelii
404621 Danio rerio
734204 Xenopus laevis
4015 Homo sapiens
100525278 Sus scrofa
280841 Bos taurus
16948 Mus musculus
24914 Rattus norvegicus
396474 Gallus gallus
481478 Canis lupus familiaris
100720740 Cavia porcellus
100357045 Oryctolagus cuniculus
101112220 Ovis aries
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