Matrix Metallopeptidase 12 (Macrophage Elastase) Proteins (MMP12)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP12 Antibodies (223) and MMP12 Kits (75) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP12 17381 P34960
MMP12 117033 Q63341
MMP12 4321 P39900
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Top MMP12 Proteins at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Rabbit His tag 100 μg Log in to see 15 to 18 Days
$848.00
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 20 to 21 Days
$437.80
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$832.00
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human MMP12 Protein. 100 μg Log in to see 11 to 18 Days
$682.25
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse MMP12 Protein. 100 μg Log in to see 11 to 18 Days
$724.89
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,995.67
Details

MMP12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,

Rat (Rattus) ,

Human , ,
,

More Proteins for Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. MMP-12 facilitates macrophage accumulation and activation in anti-GBM glomerulonephritis which is required for glomerular crescent (show SFRP5 Proteins) formation, Bowman's capsule rupture, tubular damage and renal function decline.

  2. findings define a novel physiological function of Shp2 (show PTPN11 Proteins) in TGF-beta1 (show TGFB1 Proteins)/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.

  3. Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice

  4. MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV (show COL4 Proteins) and fibronectin (show FN1 Proteins).

  5. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  6. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.

  7. study found significant increases of MMP-3 (show MMP3 Proteins) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  8. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (show F2RL1 Proteins) might be related to MMP-12 production.

  9. MMP-12 up-regulation mediated by SARM (show SARM1 Proteins)-TRIF (show RNF138 Proteins) signaling pathway contributes to IFN-gamma (show IFNG Proteins)-independent airway inflammation and AHR (show AHR Proteins) post RSV infection in nude mice.

  10. MMP-12 and MMP-13 (show MMP13 Proteins) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

Human Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma

  2. MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity.

  3. Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis]

  4. Review/Meta-analysis: MMP-1 (show MMP1 Proteins) -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.

  5. The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha (show HIF1A Proteins). These findings suggest MMP12 involved in trophoblast invasion during the first trimester.

  6. In the present report, hypoxia is shown to activate a HIF-KDM3A (show KDM3A Proteins)-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.

  7. The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease

  8. The results of this study demonstrate that the gene expression of MMP9 (show MMP9 Proteins), MMP12, TIMP1 (show TIMP1 Proteins) and TIMP2 (show TIMP2 Proteins) was influenced by the addition of TGF-beta1 (show TGFB1 Proteins). These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 (show TGFB1 Proteins) in the vein wall pathology.

  9. M4 macrophages are a possible source for HDAC9 (show HDAC9 Proteins) and MMP12 expression in advanced human carotid plaques.

  10. MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R (show CD200R1 Proteins) surface levels. MMP12 production by these cells was induced by CSF2 (show CSF2 Proteins), and treatment with a CD200R (show CD200R1 Proteins) ligand reduced CSF2 (show CSF2 Proteins)-induced MMP12 production. This novel association of the CD200 (show CD200 Proteins)/CD200R (show CD200R1 Proteins) pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

Rabbit Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.

MMP12 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP12

  • matrix metallopeptidase 12 (MMP12)
  • matrix metallopeptidase 12 (Mmp12)
  • AV378681 protein
  • HME protein
  • ME protein
  • MME protein
  • Mmel protein
  • MMP-12 protein
  • MMP12 protein

Protein level used designations for MMP12

matrix metallopeptidase 12 (macrophage elastase) , matrix metalloproteinase 12 , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase-12 , matrix metalloproteinase 12 (macrophage elastase) , macrophage metalloelastase MMP-12

GENE ID SPECIES
451512 Pan troglodytes
17381 Mus musculus
117033 Rattus norvegicus
4321 Homo sapiens
100009559 Oryctolagus cuniculus
611789 Canis lupus familiaris
526981 Bos taurus
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