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The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence.
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Human Polyclonal MDC1 Primary Antibody for ICC, IF - ABIN151859
Shi, Ma, Willers, Akhtar, Scott, Zhang, Powell, Zhang: Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation. in The Journal of biological chemistry 2008
Show all 16 Pubmed References
Human Polyclonal MDC1 Primary Antibody for IF, WB - ABIN2475546
Dranove, Shanley, White: How fast are hospital prices really rising? in Medical care 1991
Show all 4 Pubmed References
Human Polyclonal MDC1 Primary Antibody for IHC (p), IP - ABIN151860
Floyd, Pacold, Huang, Clarke, Lam, Cannell, Bryson, Rameseder, Lee, Blake, Fydrych, Ho, Greenberger, Chen, Maffa, Del Rosario, Root, Carpenter, Hahn, Sabatini, Chen, White, Bradner, Yaffe: The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. in Nature 2013
Human Polyclonal MDC1 Primary Antibody for ICC, IF - ABIN151861
Mallette, Mattiroli, Cui, Young, Hendzel, Mer, Sixma, Richard: RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. in The EMBO journal 2012
Human Polyclonal MDC1 Primary Antibody for ICC, IF - ABIN4333285
Mastrocola, Kim, Trinh, Rodenkirch, Tibbetts: The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. in The Journal of biological chemistry 2013
MDC1 plays a fundamentally significant role in maintenance of genomic stability through a DNA damage response-independent pathway.
MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.
oligomerization of MDC1 plays an important role in DDR (show DDR1 Antibodies) and help understand the formation of proteins complexes at the sites of DNA damage.
structural insight into MDC1-CHK2 (show CHEK2 Antibodies) interaction
the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells
Data show that loss of Mof (show KAT8 Antibodies) leads to reduction of histone H4 (show HIST1H4H Antibodies) K16 (show KRT16 Antibodies) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.
Data show that ATM (show ATM Antibodies)-dependent resection at a subset of DSBs leads to ATR (show ATR Antibodies)-dependent Chk1 (show CHEK1 Antibodies) activation, and that 53BP1 (show TP53BP1 Antibodies)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.
identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NBN Antibodies) (MRN) complex and factors such as gammaH2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies)
MDC1, as a signal amplifier of the ATM (show ATM Antibodies) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.
MDC1 knockdown affected the formation of telomere dysfunction-induced foci.
key component of the DNA damage response and interacts with several factors such as gamma-H2AX
It showed a link between the status of MDC1 protein and TP53 (show TP53 Antibodies) gene, which specific mutations caused radiation-induced MDC1 down-regulation.
ASF1a (show ASF1A Antibodies) promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM (show ATM Antibodies) at double-strand breaks.
the opposing activities of RNF4 (show RNF4 Antibodies) and ataxin-3 (show ATXN3 Antibodies) consolidate robust MDC1-dependent signaling and repair ofDNA double-strand break.
NFBD1 protein is overexpressed in NPC (show NPC1 Antibodies) tissues and that silencing NFBD1 can inhibit cell growth, induce apoptosis, increase the production of intracellular ROS (show ROS1 Antibodies). NFBD1 knockdown also inhibits the tumorigenicity of NPC (show NPC1 Antibodies) cells in vivo.
NFBD1 knockdown improves the chemosensitivity of NPC (show NPC1 Antibodies) cells by inhibiting cell growth and promoting apoptosis through the impairment of DNA damage repair, suggesting NFBD1 as a novel therapeutic target for NPC (show NPC1 Antibodies).
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
The interaction of MDC1 with RNF8 (show RNF8 Antibodies), but not with ATM (show ATM Antibodies) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Antibodies).
MDC1 recruits TNKS1 (show TNKS Antibodies) and TNKS2 (show TNKS2 Antibodies) to DNA lesions.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
mediation of DNA damage checkpoint 1
, mediator of DNA damage checkpoint protein 1
, homologue to Drosophila photoreceptor protein calphotin
, mediator of DNA damage checkpoint 1
, nuclear factor with BRCT domains 1