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MAGEA9 is a member of the MAGEA gene family.
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Human Polyclonal MAGEA9 Primary Antibody for IHC (p), WB - ABIN390111
Rogner, Wilke, Steck, Korn, Poustka: The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. in Genomics 1996
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MAGE-A9 overexpression promoted cell proliferation, colony formation, migration, chemoresistance, and tumorigenicity in the context of EpCAM (show EPCAM Antibodies)+ HCC (show FAM126A Antibodies) cells, whereas MAGE-A9 knockdown significantly inhibited anchorage-dependent and spheroid colony formation and in vivo tumorigenicity.
The overall survival of laryngeal squamous cell carcinoma patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression.
High expression levels of MAGE-A9 are correlated with lung adenocarcinoma.
The results showed that the high expression of MAGE-A9 protein in NSCLC tumor cells were commonly present in squamous cell carcinomas. It was also related to larger tumor diameter, lymph node metastasis and later stage grouping with TNM (show ODZ1 Antibodies) classification
These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC (show FAM126A Antibodies) and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC (show FAM126A Antibodies) patients
High expression of MAGE-A9 indicates unfavorable survival outcome in laryngeal squamous cell carcinoma patients.
The data suggest that MAGE-A9 expression is correlated with malignant attributes of invasive ductal breast cancer
MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing.
May provide suitable targets for immunotherapy of renal cell carcinoma (show MOK Antibodies).
Overexpression of MAGE-A9 is associated with bladder cancer.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
melanoma antigen family A, 9
, melanoma antigen family A, 9B
, similar to Melanoma-associated antigen 4 (MAGE-4 antigen) (MAGE-X2) (MAGE-41) (Cancer/testis antigen 1.4) (CT1.4)
, MAGE-9 antigen
, cancer/testis antigen 1.9
, cancer/testis antigen family 1, member 9
, melanoma-associated antigen 9