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Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MIXL1 Antibodies (48) and MIXL1 Kits (3) and many more products for this protein.
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Findings support the existence of a novel MIXL1-c REL (show NFkBP65 Proteins) mediated survival axis in AML (show RUNX1 Proteins) that can be targeted by BMPR1 (show BMPR1A Proteins) inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein).
results demonstrate that Mixl1 and Flk1 play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 cells.
Brachyury (show TBX1 Proteins) and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
These results demonstrate for a functional role for TGF-beta (show TGFB1 Proteins) ligands in regulation of mammalian Mixl1, identify FoxH1 (show FOXH1 Proteins) as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis.
MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis
Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis.
In this study, we demonstrated that forced expression of Mix-like protein 1 (encoded by Mixl1) can be used to guide contribution of mouse embryonic stem cells to endodermal organs after blastocyst injection.
Embryonic localization of Mixl1 shows its co-localized with the early hematopoietic marker, Runx1 (show RUNX1 Proteins), in the allantois and visceral yolk sac (show ADCY10 Proteins) blood islands.
At later stages, in contrast with wild-type embryos, E7.5-8.0, Mixl1 knockout (KO) KO/KO (show KRT8 Proteins) embryos lacked morphologically recognizable midline structures such as the node and notochord.
These data support the hypothesis that Mixl1 directly regulates Pdgfralpha and Flk1 (show KDR Proteins) gene expression.
results strongly suggest that Gsc (show GSC Proteins) is a direct target gene of Mixl1 during embryogenesis.
required for the morphogenesis of axial mesoderm, the heart and the gut (show GUSB Proteins) during embryogenesis
Mixl1 is required for efficient haematopoiesis and BMP4 (show BMP4 Proteins)-induced ventral mesoderm patterning in differentiating ES cells
all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia (show BCL11A Proteins) with a mean latency period of 200 days
As goosecoid (show GSC Proteins) is itself induced in a Foxh1 (show FOXH1 Proteins)-dependent manner, we propose that Foxh1 (show FOXH1 Proteins) initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005
Mix1 homeobox-like 1 (Xenopus laevis)
, Mix-like homeobox protein 1
, MIX1 homeobox-like protein 1
, homeobox protein MIXL1
, homeodomain protein MIX
, mix.1 homeobox-like protein
, CMIX homeobox
, Mix1 homeobox-like 1