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MDFIC product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression.
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GR directly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC activity. These findings identify a new binding partner for cytoplasmic GR that modulates the receptor transcriptome and contributes to the tissue-specific actions of glucocorticoids.
HIC specifically interacts with HTLV-1 Tax (show CNTN2 Antibodies) and negatively regulates Tax (show CNTN2 Antibodies) transactivational activity by altering its subcellular distribution and stability.
We demonstrate that HIC selectively interferes with Rev NLS interaction with importin beta and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin.
These data reveal for the first time that I-mfa (show MDFI Antibodies) domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt (show WNT2 Antibodies) signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3beta complex.
This study describes that the immune expression of HIC is cell-specific, dynamic, and identifies the HIC gene as an IL-2 (show IL2 Antibodies) responsive gene.
strict regulation of HIC expression at the levels of mRNA stability, translation efficiency and protein stability suggests that expression of the HIC protein and its involvement in the various pathways is required only under specific cellular conditions
Data indicate a role for XIC in limiting Tcf3 (show TCF3 Antibodies)-dependent repression of Siamois activities that are required for goosecoid transcription and for dorsal organizer formation.
This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization\; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.
MyoD family inhibitor domain containing
, myoD family inhibitor domain-containing protein
, myoD family inhibitor domain-containing
, I-mfa domain-containing protein
, MyoD family inhibitor domain containing protein
, kidney cell line-derived transcript 1
, kidney cell line derived transcript 1
, I-mfa domain protein XIC